Harvey S, Hall T R
Gen Comp Endocrinol. 1987 Feb;65(2):264-8. doi: 10.1016/0016-6480(87)90174-2.
Sodium pentobarbitone anaesthesia lowered the circulating growth hormone (GH) concentration in immature chickens and reduced basal and stimulated pituitary GH release in vitro. The immunoneutralization of endogenous somatostatin (SRIF), by passive SRIF immunization, overcame the inhibitory effect of anaesthesia on basal GH secretion in vivo, but had no direct effects on GH release in vitro. However, while SRIF immunization restored the resting GH concentration in the anaesthetized birds, it increased greatly the GH level in conscious birds. These results therefore suggest that the inhibition of GH secretion in anaesthetized birds may be partly SRIF-mediated, although a suppression of hypothalamic stimulation may also be involved.
戊巴比妥钠麻醉降低了未成熟鸡的循环生长激素（GH）浓度，并在体外降低了基础和刺激状态下垂体GH的释放。通过被动免疫生长抑素（SRIF）对内源性生长抑素进行免疫中和，克服了麻醉对体内基础GH分泌的抑制作用，但对体外GH释放没有直接影响。然而，虽然SRIF免疫恢复了麻醉鸟类的静息GH浓度，但它却大大提高了清醒鸟类的GH水平。因此，这些结果表明，麻醉鸟类中GH分泌的抑制可能部分由SRIF介导，尽管也可能涉及下丘脑刺激的抑制。
