Hu Xu, Jiang Linfei, Tang Chenhui, Ju Yuehong, Jiu Li, Wei Yongyue, Guo Li, Zhao Yang
Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
J Biomed Res. 2017 Jan 19;31(3):213-225. doi: 10.7555/JBR.31.20160087.
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants ofESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA+ GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms ofESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.
雌激素受体的表达与乳腺癌风险相关，但报道结果并不一致。为了阐明潜在的雌激素受体（ESR）相关的乳腺癌风险，我们分析了ESR1的基因变异与乳腺癌易感性的关系。我们进行了一项荟萃分析，以研究rs2234693、rs1801132和rs2046210（ESR1的单核苷酸多态性）与乳腺癌风险之间的关联。我们的分析纳入了44项病例对照研究。对于rs2234693，与TT或CT基因型相比，CC基因型患乳腺癌的风险更高。对于rs2046210，与GG基因型相比，AA、GA或GA + GG基因型患乳腺癌的风险要高得多。未发现rs1801132多态性与乳腺癌风险有显著关联。这项荟萃分析表明ESR1的rs2234693和rs2046210多态性与乳腺癌风险之间存在关联。rs2234693与乳腺癌易感性之间的相关强度在按种族进行的亚组评估中有所不同。
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