Department of Molecular Biology, University of Bergen, Thormøhlensgate 55, NO-5006, Bergen, Norway.
Department of Chemistry, University of Oslo, P. O. Box 1033, Blindern, NO-0315, Oslo, Norway.
Sci Rep. 2017 Aug 14;7(1):8012. doi: 10.1038/s41598-017-06855-z.
This paper reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halve during elongation of the Gram-positive bacterium Listeria innocua. The lyotropic phase behaviour of model lipid systems that describe these modulations in lipid composition indicate that the average stored curvature elastic stress of the membrane is reduced on elongation of the cell, while the fluidity appears to be maintained. These findings suggest that phospholipid metabolism is linked to the cell cycle and that changes in membrane composition can facilitate passage to the succeding stage of the cell cycle. This therefore suggests a means by which bacteria can manage the physical properties of their membranes through the cell cycle.
本文报道称，革兰氏阳性菌无害李斯特菌伸长过程中，内源性心磷脂和磷脂酰乙醇胺的丰度减半。描述这些脂质组成变化的模型脂质系统的溶致相行为表明，细胞膜的平均储存曲率弹性应力在细胞伸长时降低，而流动性似乎得以维持。这些发现表明，磷脂代谢与细胞周期有关，膜组成的变化可以促进细胞周期的下一阶段。因此，这表明了细菌可以通过细胞周期来管理其膜的物理性质的一种方式。
