Tehrani Hatav Ghasemi, Mostajeran Fatemeh, Banihashemi Behnaz
Department of Obstetrics and Genecology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Jul 14;6:79. doi: 10.4103/2277-9175.210658. eCollection 2017.
The aim of this study was survey of the effect of Vitamin D supplementation on the incidence of gestational diabetes (GDM) in pregnant women.
This randomized clinical trial was conducted at Alzahra and Shahid Beheshti Hospital in Isfahan, Iran, from January, 2013 to January, 2014 on 210 pregnant women referred to gynecology clinics. Serum levels of Vitamin D were measured, and those with lower serum levels of 10 nmol/L randomly divided into two groups of A and B. Pregnant women with normal Vitamin D level assigned as Group C. Group A was given 50,000 IU Vitamin D supplement every 2 weeks for 10 weeks, and Group B were given the omega-3 pearl as placebo. Then, the incidence of GDM was measured in 24-26 weeks of pregnancy with glucose tolerance test and compared in three groups. Data were analyzed using SPSS version 20 by descriptive statistics, Chi-square and Logistic regression.
The mean age of participants was 24.76 years (8.02 standard deviation, range 16-36 years). The incidence of GDM at 24-26 weeks gestational age were 8.57% in normal Vitamin D group, 10.00% in Vitamin D deficiency with treatment group, and 11.43% in Vitamin D deficiency without treatment group. The difference between groups in terms of incidence of GDM was not statistically significant ( = 0.112).
Vitamin D supplementation had not effect on incidence of GDM during pregnancy.
本研究旨在调查补充维生素D对孕妇妊娠糖尿病（GDM）发病率的影响。
本随机临床试验于2013年1月至2014年1月在伊朗伊斯法罕的阿尔扎赫拉医院和沙希德·贝赫什提医院对210名转诊至妇科诊所的孕妇进行。测量血清维生素D水平，血清水平低于10 nmol/L的孕妇随机分为A组和B组。维生素D水平正常的孕妇作为C组。A组每2周给予50000 IU维生素D补充剂，共10周，B组给予ω-3珍珠作为安慰剂。然后，在妊娠24 - 26周时通过葡萄糖耐量试验测量GDM的发病率，并在三组中进行比较。使用SPSS 20版进行描述性统计、卡方检验和逻辑回归分析数据。
参与者的平均年龄为24.76岁（标准差8.02，范围16 - 36岁）。维生素D正常组在孕24 - 26周时GDM的发病率为8.57%，维生素D缺乏治疗组为10.00%，维生素D缺乏未治疗组为11.43%。三组之间GDM发病率的差异无统计学意义（P = 0.112）。
补充维生素D对孕期GDM的发病率没有影响。
