Kornienko Alexander, La Clair James J
Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Nat Prod Rep. 2017 Aug 30;34(9):1051-1060. doi: 10.1039/c7np00024c.
Covering: up to June 2017Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.
截至2017年6月
天然产物和内源性代谢物通过复杂机制作用于组织和细胞内的特定靶点。本综述考察了天然系统采用帕尔-克诺尔反应作用于生物靶点中亲核胺基的程度。目前对这种反应模式的理解仅限于该反应在生物学背景下的少数例子。本亮点旨在激发科学界确定帕尔-克诺尔反应在天然和工程生物系统中的潜在研究方向及应用。
