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盐酸多柔比星在氧化石墨烯上的吸附特性：平衡、动力学及热力学研究

Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies.

作者信息

Wu Shaoling, Zhao Xindong, Li Yanhui, Du Qiuju, Sun Jiankun, Wang Yonghao, Wang Xin, Xia Yanzhi, Wang Zonghua, Xia Linhua

机构信息

Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China.

Department of Hematology, the Affiliated Hospital of medical College, 16 Jiangsu Road, Qingdao, Shandong 266003, China.

出版信息

Materials (Basel). 2013 May 15;6(5):2026-2042. doi: 10.3390/ma6052026.

DOI:10.3390/ma6052026
PMID:28809258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5452512/
Abstract

Doxorubicin hydrochloride (DOX) is an effective anticancer agent for leukemia chemotherapy, although its clinical use has been limited because of its side effects such as cardiotoxicity, alopecia, vomiting, and leucopenia. Attention has been focussed on developing new drug carriers with high adsorption capacity and rapid adsorption rate in order to minimize the side effects of DOX. Graphene oxide (GO), a new type of nanomaterial in the carbon family, was prepared by Hummers method and used as adsorbent for DOX from aqueous solution. The physico-chemical properties of GO were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), zeta potential, and element analysis. The adsorption properties of DOX on GO were studied as a function of contact time, adsorbent dosage, temperature and pH value. The results showed that GO had a maximum adsorption capacity of 1428.57 mg/g and the adsorption isotherm data fitted the Langmuir model. The kinetics of adsorption fits a pseudo-second-order model. The thermodynamic studies indicate that the adsorption of DOX on GO is spontaneous and endothermic in nature.

摘要

盐酸阿霉素（DOX）是白血病化疗的一种有效抗癌药物，尽管由于其心脏毒性、脱发、呕吐和白细胞减少等副作用，其临床应用受到限制。为了将DOX的副作用降至最低，人们一直致力于开发具有高吸附容量和快速吸附速率的新型药物载体。氧化石墨烯（GO）是碳族中的一种新型纳米材料，通过Hummers法制备，并用作从水溶液中吸附DOX的吸附剂。通过透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）、zeta电位和元素分析对GO的物理化学性质进行了表征。研究了DOX在GO上的吸附特性与接触时间、吸附剂用量、温度和pH值的关系。结果表明，GO的最大吸附容量为1428.57 mg/g，吸附等温线数据符合Langmuir模型。吸附动力学符合准二级模型。热力学研究表明，DOX在GO上的吸附是自发的，本质上是吸热的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/66af69b88461/materials-06-02026-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/af409904ad4e/materials-06-02026-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/370ee87633f9/materials-06-02026-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/581f72974078/materials-06-02026-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/c257935d74f6/materials-06-02026-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/66af69b88461/materials-06-02026-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/c2b93b240bf3/materials-06-02026-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/e398333bd58a/materials-06-02026-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/af409904ad4e/materials-06-02026-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/370ee87633f9/materials-06-02026-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/581f72974078/materials-06-02026-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/c257935d74f6/materials-06-02026-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/5452512/66af69b88461/materials-06-02026-g007.jpg

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