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Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin.

作者信息

Hasanin Mohamed, Taha Nesrin Fouad, Abdou Aya Rashad, Emara Laila Hasanin

机构信息

Cellulose and Paper Department Chemical Research Institute, National Research Centre, 33 EL Bohouth st. (former EL Tahrir st.), Dokki, Giza, P.O.12622 Egypt.

Medicinal and Pharmaceutical Chemistry Department Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 EL Bohouth st. (former EL Tahrir st.), Dokki, Giza, P.O.12622 Egypt.

出版信息

Biotechnol Rep (Amst). 2022 Mar 18;34:e00722. doi: 10.1016/j.btre.2022.e00722. eCollection 2022 Jun.

DOI:10.1016/j.btre.2022.e00722
PMID:35686004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9171453/
Abstract

Tri-nanocomposite system of biocompatible polymers (gelatin/gum arabic) functionalized onto graphene-oxide nanosheets for controlling the release of an anticancer, doxorubicin (DOX), was fabricated via green-biosynthesis. Biocompatibility and nano-size stability of the tri-nanocomposite was characterized by SEM, TEM, FTIR, XRD, and zeta-potential. Loading-efficiency, release-behavior and cytotoxic-activity of DOX-loaded-composite in WI-38 normal-lung-fibroblast and A549 lung-carcinoma cells were investigated. High DOX-loading (at pH 9.5), with pH-sensitive release from loaded-composite was achieved, with 25% and 77% DOX released, at physiological pH 7.4 and cancerous pH 5.3, respectively. Stability of tri-nanocomposite system was confirmed over 3-months storage at accelerated conditions, as presented by FTIR, XRD, TEM, zeta-potential and in-vitro release assays. High proliferative inhibitory effect of DOX loaded-composite, on A549-cells, with minimal toxicity on WI-38-cells, with IC values of 51.9 ± 0.46 and 185±1.08 µg/mL, against A549 and WI-38, respectively. Proposed tri-nanocomposite offers a novel combination of gelatin/gum arabic with graphene-oxide for targeted drug-delivery and efficient anti-cancer therapy.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/f11b2a3e640d/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/2cea6bf510f6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/a5e20f67c64b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4ecdf31016d7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4aeb5653631a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/497c30bc2c2b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/9c955d90c6ef/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4ece5ac21624/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/191cea44a72b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/f11b2a3e640d/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/2cea6bf510f6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/a5e20f67c64b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4ecdf31016d7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4aeb5653631a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/497c30bc2c2b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/9c955d90c6ef/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/4ece5ac21624/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/191cea44a72b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963d/9171453/f11b2a3e640d/gr9.jpg

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本文引用的文献

[1]
A porous reduced graphene oxide/chitosan-based nanocarrier as a delivery system of doxorubicin.

RSC Adv. 2019-9-27

[2]
A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy.

Nanoscale Horiz. 2022-1-31

[3]
Preparation and characterization of Gum Arabic Schiff's bases based on 9-aminoacridine with in vitro evaluation of their antimicrobial and antitumor potentiality.

Carbohydr Polym. 2022-2-1

[4]
A new approach for antimicrobial and antiviral activities of biocompatible nanocomposite based on cellulose, amino acid and graphene oxide.

Colloids Surf B Biointerfaces. 2022-1

[5]
Hydroxypropyl methylcellulose/graphene oxide composite as drug carrier system for 5-fluorouracil.

Biotechnol J. 2022-4

[6]
Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(-Hydroxyphenyl)porphyrin.

Molecules. 2021-6-10

[7]
Predicting the Adsorption of Amoxicillin and Ibuprofen on Chitosan and Graphene Oxide Materials: A Density Functional Theory Study.

Polymers (Basel). 2021-5-17

[8]
Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes.

BMC Chem. 2021-4-24

[9]
Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy.

J Colloid Interface Sci. 2021-7-15

[10]
Enhancing the Antifungal Activity of Griseofulvin by Incorporation a Green Biopolymer-Based Nanocomposite.

Polymers (Basel). 2021-2-12

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