Li Yunshan, He Yaodong, Xiang Junwei, Feng Linfei, Wang Yuanyin, Chen Ran
College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, 230032, People's Republic of China.
Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
J Inflamm Res. 2022 Jul 26;15:4261-4274. doi: 10.2147/JIR.S369304. eCollection 2022.
Non-coding RNAs (ncRNAs) are transcribed from the genomes of mammals and other complex organisms, and many of them are alternately spliced and processed into smaller products. Types of ncRNAs include microRNAs (miRNAs), circular RNAs, and long ncRNAs. miRNAs are about 21 nucleotides long and form a broad class of post-transcriptional regulators of gene expression that affect numerous developmental and physiological processes in eukaryotes. They usually act as negative regulators of mRNA expression through complementary binding sequences in the 3'-UTR of the target mRNA, leading to translation inhibition and target degradation. In recent years, the importance of ncRNA in oral lichen planus (OLP), particularly miRNA, has attracted extensive attention. However, the biological functions of miRNAs and their mechanisms in OLP are still unclear. In this review, we discuss the role and function of miRNAs in OLP, and we also describe their potential functional roles as biomarkers for the diagnosis of OLP. MiRNAs are promising new therapeutic targets, but more work is needed to understand their biological functions.
非编码RNA（ncRNAs）由哺乳动物和其他复杂生物体的基因组转录而来，其中许多经过可变剪接并加工成更小的产物。ncRNAs的类型包括微小RNA（miRNAs）、环状RNA和长链非编码RNA。miRNAs长度约为21个核苷酸，构成一类广泛的基因表达转录后调节因子，影响真核生物众多发育和生理过程。它们通常通过与靶标mRNA的3'-UTR中的互补结合序列作为mRNA表达的负调节因子，导致翻译抑制和靶标降解。近年来，ncRNA在口腔扁平苔藓（OLP）中的重要性，尤其是miRNA，已引起广泛关注。然而，miRNAs在OLP中的生物学功能及其机制仍不清楚。在本综述中，我们讨论了miRNAs在OLP中的作用和功能，还描述了它们作为OLP诊断生物标志物的潜在功能作用。miRNAs是很有前景的新治疗靶点，但需要更多研究来了解它们的生物学功能。
