IEEE Trans Neural Syst Rehabil Eng. 2018 Jan;26(1):11-17. doi: 10.1109/TNSRE.2017.2737954. Epub 2017 Aug 10.
Kilohertz electrical stimulation (KES) has enabled a novel new paradigm for spinal cord and peripheral nerve stimulation to treat a variety of neurological diseases. KES can excite or inhibit nerve activity and is used in many clinical devices today. However, the impact of different electrode materials on the efficacy of KES is unknown. We investigated the effect of different electrode materials and their respective charge injection mechanisms on KES nerve block thresholds using 20- and 40-kHz current-controlled sinusoidal KES waveforms. We evaluated the nerve block threshold and the power requirements for achieving an effective KES nerve block. In addition, we evaluated potential effects on the onset duration and recovery of normal conduction after delivery of KES. We found that thresholds and the onset and recovery of KES nerve block are not a function of the electrode material. In contrast, the power dissipation varies among electrode materials and is a function of the materials' properties at high frequencies. We conclude that materials with a proven track record of chronic stability, both for the tissue and electrode, are suitable for developing KES nerve block therapies.
千赫兹电刺激（KES）为脊髓和周围神经刺激开辟了一种新的治疗各种神经疾病的新方法。KES 可以兴奋或抑制神经活动，目前已在许多临床设备中使用。然而，不同电极材料对 KES 疗效的影响尚不清楚。我们使用 20kHz 和 40kHz 电流控制正弦 KES 波研究了不同电极材料及其各自的电荷注入机制对 KES 神经阻滞阈值的影响。我们评估了神经阻滞阈值和实现有效 KES 神经阻滞所需的功率。此外，我们还评估了 KES 传递后对正常传导起始持续时间和恢复的潜在影响。我们发现，阈值以及 KES 神经阻滞的起始和恢复与电极材料无关。相比之下，电极材料的功耗因材料而异，并且是高频下材料特性的函数。我们得出结论，对于组织和电极都具有慢性稳定性良好记录的材料，适合开发 KES 神经阻滞疗法。
