IEEE Trans Neural Syst Rehabil Eng. 2019 May;27(5):836-845. doi: 10.1109/TNSRE.2019.2909165. Epub 2019 Apr 4.
Direct current (DC) nerve block has been shown to provide a complete block of nerve conduction without unwanted neural firing. Previous work shows that high capacitance electrodes can be used to safely deliver a DC block. Another way of delivering DC safely is through a separated interface nerve electrode (SINE), such that any reactive species that are generated by the passage of DC are contained in a vessel away from the nerve. This design has been enhanced by using a high capacitance carbon "slurry" as the electrode in the external vessel to extend the capacity of the electrode (CSINE). With this new design, it was possible to provide 50 min of continuous nerve block without recharge while still maintaining complete recovery of neural signals. Up to 46 C of charge delivery was applied for a total of 4 h of nerve block with complete recovery. Because of the extended delivery time, it was possible to explore several properties of DC block that would not be revealed without the capability of a long-duration continuous block. It was possible to achieve complete block at lower values of DC if the block was applied for a longer period of time. Depending on the amount of charge applied during the block, the recovery was delayed for a period of time before complete force recovery was restored. These new properties provide novel techniques for device development to optimize charge delivery time and device powering concerns.
直流电（DC）神经阻滞已被证明可在不引起不必要的神经放电的情况下完全阻断神经传导。先前的工作表明，高电容电极可用于安全地输送 DC 阻断。另一种安全输送 DC 的方法是通过分离的接口神经电极（SINE），使得任何由 DC 导通产生的反应性物质都包含在远离神经的容器中。通过使用高电容碳“浆料”作为外部容器中的电极，这种设计得到了增强，以延长电极的容量（CSINE）。通过这种新设计，有可能在不进行充电的情况下提供长达 50 分钟的连续神经阻滞，同时仍保持神经信号的完全恢复。总共施加了 46 摄氏度的电荷传递，用于总共 4 小时的神经阻滞，完全恢复。由于输送时间延长，有可能探索到没有长时间连续阻断能力就无法揭示的 DC 阻断的几个特性。如果阻断时间延长，则可以在较低的 DC 值下实现完全阻断。根据阻断期间施加的电荷量，在完全恢复力之前，恢复会延迟一段时间。这些新特性为优化电荷输送时间和设备供电问题的设备开发提供了新的技术。
