人心肌细胞的再生：来自放射性坠尘的启示。
Cardiomyocyte renewal in the human heart: insights from the fall-out.
机构信息
Department of Cell and Molecular Biology, Karolinska Institute, Berzelius väg 35, Stockholm SE 171 65, Sweden.
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
出版信息
Eur Heart J. 2017 Aug 7;38(30):2333-2342. doi: 10.1093/eurheartj/ehx343.
Abstract
The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.
摘要
几十年来，关于哺乳动物心脏的再生能力一直存在争议。然而，现有的追踪和识别新生心肌细胞的技术存在局限性，这往往导致结果不一致。放射性碳（14C）出生标记与其他定量策略相结合，可确定人类心肌细胞的数量和年龄，从而有可能描述其年龄分布和更替动态。准确估计成年心脏中的心肌细胞生成可以为旨在刺激各种心脏病变中心肌细胞更新的新型再生策略提供基础。
相似文献
1
Cardiomyocyte renewal in the human heart: insights from the fall-out.人心肌细胞的再生：来自放射性坠尘的启示。
Eur Heart J. 2017 Aug 7;38(30):2333-2342. doi: 10.1093/eurheartj/ehx343.
2
Dating the Heart: Exploring Cardiomyocyte Renewal in Humans.心脏的年代测定：探索人类心肌细胞更新
Physiology (Bethesda). 2017 Jan;32(1):33-41. doi: 10.1152/physiol.00015.2016.
3
Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.成人心肌细胞细胞周期的旁路：通向静止目的地的支路。
Trends Endocrinol Metab. 2019 Aug;30(8):557-567. doi: 10.1016/j.tem.2019.05.006. Epub 2019 Jun 28.
4
Polyploidy in Cardiomyocytes: Roadblock to Heart Regeneration?心肌细胞中的多倍体：心脏再生的障碍？
Circ Res. 2020 Feb 14;126(4):552-565. doi: 10.1161/CIRCRESAHA.119.315408. Epub 2020 Feb 13.
5
Building and re-building the heart by cardiomyocyte proliferation.通过心肌细胞增殖构建和重塑心脏。
Development. 2016 Mar 1;143(5):729-40. doi: 10.1242/dev.132910.
6
Cardiomyocyte death and renewal in the normal and diseased heart.正常及患病心脏中的心肌细胞死亡与更新
Cardiovasc Pathol. 2008 Nov-Dec;17(6):349-74. doi: 10.1016/j.carpath.2008.02.004. Epub 2008 Apr 1.
7
Role of Mononuclear Cardiomyocytes in Cardiac Turnover and Regeneration.单核心肌细胞在心脏更新和再生中的作用。
Curr Cardiol Rep. 2020 May 19;22(6):39. doi: 10.1007/s11886-020-01289-y.
8
Cardiomyocyte Proliferation for Therapeutic Regeneration.心肌细胞增殖治疗再生。
Curr Cardiol Rep. 2018 Jun 14;20(8):63. doi: 10.1007/s11886-018-1011-x.
9
The cardiomyocyte cell cycle in hypertrophy, tissue homeostasis, and regeneration.心肌细胞在肥大、组织稳态和再生中的细胞周期。
Rev Physiol Biochem Pharmacol. 2013;165:67-96. doi: 10.1007/112_2013_12.
10
The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin.利用和滥用 Cre/Lox 重组技术来鉴定成年心肌细胞的更新率和起源。
Pharmacol Res. 2018 Jan;127:116-128. doi: 10.1016/j.phrs.2017.06.012. Epub 2017 Jun 24.
引用本文的文献
1
The emerging role of tissue regulatory T cells in tissue repair and regeneration.组织调节性T细胞在组织修复和再生中的新作用。
Front Immunol. 2025 Aug 29;16:1640113. doi: 10.3389/fimmu.2025.1640113. eCollection 2025.
2
Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury.网络建模预测DYRK1A抑制如何促进缺血/再灌注损伤后心肌细胞的循环。
bioRxiv. 2025 Aug 25:2025.08.19.671147. doi: 10.1101/2025.08.19.671147.
3
The important regulatory role of glucose concentration in the maturation of stem cell-derived cardiomyocytes: A review.葡萄糖浓度在干细胞衍生心肌细胞成熟中的重要调节作用：综述
Medicine (Baltimore). 2025 Aug 15;104(33):e43878. doi: 10.1097/MD.0000000000043878.
4
Metabolism-related gene PDK1 regulates myocardial cell remodeling and its mechanism.代谢相关基因PDK1调控心肌细胞重塑及其机制。
Stem Cell Res Ther. 2025 Jul 26;16(1):404. doi: 10.1186/s13287-025-04518-9.
5
Association between hypertension and oxidative balance score: data from National Health and Nutrition Examination Survey 2005-2018.高血压与氧化平衡评分之间的关联：来自2005 - 2018年美国国家健康与营养检查调查的数据。
Front Cardiovasc Med. 2025 Jun 24;12:1538095. doi: 10.3389/fcvm.2025.1538095. eCollection 2025.
6
The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation.细胞外基质在诱导心脏细胞再生和分化中的作用。
Cells. 2025 Jun 10;14(12):875. doi: 10.3390/cells14120875.
7
An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart.再生斑马鱼心脏的全器官时空转录组学和细胞图谱
Nat Commun. 2025 Apr 19;16(1):3716. doi: 10.1038/s41467-025-59070-0.
8
Heart Failure in Older Patients: An Update.老年患者心力衰竭：最新进展
J Clin Med. 2025 Mar 14;14(6):1982. doi: 10.3390/jcm14061982.
9
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line.通过转基因报告系证明成年热带爪蟾中心肌细胞的增殖与心脏再生
NPJ Regen Med. 2024 Dec 19;9(1):40. doi: 10.1038/s41536-024-00384-w.
10
Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling.糖原合酶激酶-3抑制和胰岛素通过TCF和FOXO信号通路增强人诱导多能干细胞衍生心肌细胞的增殖并抑制其成熟。
Stem Cell Reports. 2025 Jan 14;20(1):102371. doi: 10.1016/j.stemcr.2024.11.001. Epub 2024 Dec 5.
本文引用的文献
1
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.H3K9二甲基转移酶EHMT1/2可预防病理性心脏肥大。
J Clin Invest. 2017 Jan 3;127(1):335-348. doi: 10.1172/JCI88353. Epub 2016 Nov 28.
2
Hypoxia induces heart regeneration in adult mice.缺氧诱导成年小鼠心脏再生。
Nature. 2017 Jan 12;541(7636):222-227. doi: 10.1038/nature20173. Epub 2016 Oct 31.
3
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.iPS 细胞源性心肌细胞的同种异体移植可使灵长类动物心脏再生。
Nature. 2016 Oct 20;538(7625):388-391. doi: 10.1038/nature19815. Epub 2016 Oct 10.
4
Systematic selection of small molecules to promote differentiation of embryonic stem cells and experimental validation for generating cardiomyocytes.用于促进胚胎干细胞分化并生成心肌细胞的小分子的系统筛选及实验验证。
Cell Death Discov. 2016 Feb 8;2:16007. doi: 10.1038/cddiscovery.2016.7. eCollection 2016.
5
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.小分子将人成纤维细胞转化为功能性心肌细胞。
Science. 2016 Jun 3;352(6290):1216-20. doi: 10.1126/science.aaf1502. Epub 2016 Apr 28.
6
Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation.迈向哺乳动物心脏再生：评估实验诱导的成年哺乳动物心肌细胞增殖所面临的挑战。
Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1045-54. doi: 10.1152/ajpheart.00697.2015. Epub 2016 Feb 26.
7
Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year.急性心肌梗死后给予c-kit（阳性）心脏祖细胞的长期结果：移植细胞不会变成心肌细胞，但内源性细胞的结构和功能改善以及增殖至少持续一年。
Circ Res. 2016 Apr 1;118(7):1091-105. doi: 10.1161/CIRCRESAHA.115.307647. Epub 2016 Feb 2.
8
Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association.《2016年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2016 Jan 26;133(4):e38-360. doi: 10.1161/CIR.0000000000000350. Epub 2015 Dec 16.
9
Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.遗传谱系追踪鉴定出原位表达Kit的心肌细胞。
Cell Res. 2016 Jan;26(1):119-30. doi: 10.1038/cr.2015.143. Epub 2015 Dec 4.
10
No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice.青春期前小鼠心肌细胞数量无扩增证据。
Cell. 2015 Nov 5;163(4):1026-36. doi: 10.1016/j.cell.2015.10.035.
Zotero 插件