State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Sci Rep. 2017 Aug 15;7(1):8167. doi: 10.1038/s41598-017-08238-w.
In recent years, magnesium (Mg) alloys show a promising application in clinic as degradable biomaterials. Nevertheless, the poor corrosion resistance of Mg alloys is the main obstacle to their clinical application. Here we successfully seal the pores of plasma electrolytic oxidation (PEO) coating on AZ31 with Mg-Al layered double hydroxide (LDH) via hydrothermal treatment. PEO/LDH composite coating possess a two layer structure, an inner layer made up of PEO coating (5 μm) and an outer layer of Mg-Al LDH (2 μm). Electrochemical and hydrogen evolution tests suggest preferable corrosion resistance of the PEO/LDH coating. Cytotoxicity, cell adhesion, live/dead staining and proliferation data of rat bone marrow stem cells (rBMSCs) demonstrate that PEO/LDH coating remarkably enhance the cytocompatibility of the substrate, indicating a potential application in orthopedic surgeries. In addition, hemolysis rate (HR) test shows that the HR value of PEO/LDH coating is 1.10 ± 0.47%, fulfilling the request of clinical application. More importantly, the structure of Mg-Al LDH on the top of PEO coating shows excellent drug delivery ability.
近年来，镁（Mg）合金作为可降解生物材料在临床上显示出了广阔的应用前景。然而，镁合金较差的耐腐蚀性是其临床应用的主要障碍。在这里，我们通过水热处理成功地用镁铝层状双氢氧化物（LDH）对 AZ31 等离子电解氧化（PEO）涂层的孔隙进行了密封。PEO/LDH 复合涂层具有双层结构，内层由 PEO 涂层（5μm）和外层的 Mg-Al LDH（2μm）组成。电化学和析氢测试表明，PEO/LDH 涂层具有更好的耐腐蚀性。大鼠骨髓间充质干细胞（rBMSCs）的细胞毒性、细胞黏附、死活染色和增殖数据表明，PEO/LDH 涂层显著提高了基底的细胞相容性，表明其在骨科手术中有潜在的应用。此外，溶血率（HR）测试表明，PEO/LDH 涂层的 HR 值为 1.10±0.47%，满足临床应用的要求。更重要的是，PEO 涂层顶部的 Mg-Al LDH 结构具有优异的药物输送能力。
