a Department of Orthopedic Surgery , Akita University Graduate School of Medicine , 1-1-1 Hondo , Akita 010-8543 , Japan.
b Department of Orthopedic Surgery , Sapporo Medical University School of Medicine , S-1 W-16, Cyuo-ku , Sapporo, Hokkaido 060-8543 , Japan.
Ups J Med Sci. 2017 Aug;122(3):190-193. doi: 10.1080/03009734.2017.1356404. Epub 2017 Aug 17.
A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about distant metastasis is sparse. We evaluated the tendency of clinical and histological features of metastasis in myxofibrosarcoma patients.
Fifty-eight patients with myxofibrosarcoma were treated in our hospitals, and a total of 16 consecutive patients with distant metastases were included in this retrospective study (9 males and 7 females, with a mean age of 77 years). Because there was no patient complicated by both lung and lymph node metastases, we compared the age, sex, tumor size and location, French Federation of Cancer Centers Sarcoma Group (FNCLCC) grade, American Joint Committee on Cancer (AJCC) stage, and times of the first metastasis from the initial examination between the lung and lymph node groups. In addition, we examined factors affecting the prognosis.
The median follow-up period was 42.9 months (range 8-142). Eleven of 16 patients developed pulmonary metastases. The sites of extra pulmonary metastases were the lymph nodes in 5 patients, bone in 1, subcutaneous in 1, intramuscular in 1, and peritoneum in 1. The median time for patients to develop distant metastases was 17.4 months (range 0-59). The time until the onset of the first metastasis in the lung metastasis group was significantly shorter than in the lymph node group (p < 0.05). Also, the survival rate in the lymph node metastasis group was better than in the lung metastasis group (p < 0.05).
Not only lung metastasis but also lymph node metastasis occurs frequently in myxofibrosarcoma patients. Myxofibrosarcoma with lung metastasis is more aggressive than the type with lymph node metastasis.
黏液纤维肉瘤的一个临床特征是局部复发，但对远处转移的了解较少。我们评估了黏液纤维肉瘤患者转移的临床和组织学特征的倾向。
我们医院治疗了 58 例黏液纤维肉瘤患者，其中有 16 例连续发生远处转移的患者（9 名男性，7 名女性，平均年龄 77 岁）被纳入本回顾性研究。由于没有同时合并肺和淋巴结转移的患者，我们比较了肺组和淋巴结组之间的年龄、性别、肿瘤大小和位置、法国癌症中心肉瘤联合会（FNCLCC）分级、美国癌症联合委员会（AJCC）分期以及首次转移的时间。此外，我们还检查了影响预后的因素。
中位随访时间为 42.9 个月（范围 8-142）。16 例患者中有 11 例发生了肺转移。肺外转移部位为淋巴结 5 例，骨 1 例，皮下 1 例，肌内 1 例，腹膜 1 例。患者发生远处转移的中位时间为 17.4 个月（范围 0-59）。肺转移组患者出现首次转移的时间明显短于淋巴结转移组（p<0.05）。此外，淋巴结转移组的生存率优于肺转移组（p<0.05）。
黏液纤维肉瘤患者不仅发生肺转移，而且还常发生淋巴结转移。肺转移的黏液纤维肉瘤比淋巴结转移的黏液纤维肉瘤更具侵袭性。
