Wu Yi-Hang, Zhang Bing-Yi, Qiu Li-Peng, Guan Rong-Fa, Ye Zi-Hong, Yu Xiao-Ping
Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China.
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Curr Med Chem. 2017;24(38):4279-4302. doi: 10.2174/0929867324666170815102917.
A great effort has been made to develop efficacious antiviral drugs, but many viral infections are still lack of efficient antiviral therapies so far. The related exploration of natural products to fight viruses has been raised in recent years. Natural compounds with structural diversity and complexity offer a great chance to find new antiviral agents. Particularly, phenolic acids have attracted considerable attention owing to their potent antiviral abilities and unique mechanisms. The aim of this review is to report new discoveries and updates pertaining to antiviral phenolic acids.
The relevant references on natural phenolic acids were searched. The antiviral phenolic acids were classified according to their structural properties and antiviral types. Meanwhile, the antiviral characteristics and structure-activity relationships of phenolic acids and their derivatives were summarized.
The review finds that natural phenolic acids and their derivatives possessed potent inhibitory effects on multiple virus in humans such as human immunodeficiency virus, hepatitis C virus, hepatitis B virus, herpes simplex virus, influenza virus and respiratory syncytial virus. In particular, caffeic acid/gallic acid and their derivatives exhibited outstanding antiviral properties by a variety of modes of action.
Naturally derived phenolic acids especially caffeic acid/gallic acid and their derivatives may be regarded as novel promising antiviral leads or candidates. Additionally, scarcely any of these compounds has been used as antiviral treatment in clinical practice. Therefore, these phenolic acids with diverse skeletons and mechanisms provide us an excellent resource for finding novel antiviral drugs.
人们已付出巨大努力研发有效的抗病毒药物，但到目前为止，许多病毒感染仍缺乏有效的抗病毒治疗方法。近年来，对天然产物抗御病毒的相关探索不断增加。结构多样且复杂的天然化合物为寻找新型抗病毒药物提供了巨大机会。特别是酚酸，因其强大的抗病毒能力和独特机制而备受关注。本综述旨在报告与抗病毒酚酸相关的新发现和新进展。
检索了有关天然酚酸的相关参考文献。根据其结构特性和抗病毒类型对抗病毒酚酸进行了分类。同时，总结了酚酸及其衍生物的抗病毒特性和构效关系。
该综述发现，天然酚酸及其衍生物对多种人类病毒具有强大的抑制作用，如人类免疫缺陷病毒、丙型肝炎病毒、乙型肝炎病毒、单纯疱疹病毒、流感病毒和呼吸道合胞病毒。特别是，咖啡酸/没食子酸及其衍生物通过多种作用方式表现出卓越的抗病毒特性。
天然来源的酚酸，尤其是咖啡酸/没食子酸及其衍生物，可被视为有前景的新型抗病毒先导物或候选药物。此外，这些化合物几乎都尚未在临床实践中用作抗病毒治疗。因此，这些具有不同骨架和作用机制的酚酸为我们寻找新型抗病毒药物提供了极佳资源。
