Department of Hospital Pediatrics, Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.
Department of Children's Diseases, I.M. Sechenov First Moscow State Medical University, 8/2 Trubetskaya St., Moscow 119991, Russia.
Can Respir J. 2017;2017:8761404. doi: 10.1155/2017/8761404. Epub 2017 Jul 26.
Influence of bronchial asthma (BA) severity on physical development in children patients was evaluated in comparison with healthy population. . 1042 children and adolescents (768 boys) with atopic BA were evaluated. All children underwent standard examination in a clinical setting, including anthropometry. The control group included 875 healthy children of a comparable age (423 boys). . The fraction of patients with the normal, lower, and increased height among the whole group of patients with BA is close to the corresponding values in the healthy population ( = 3.32, = 0.65). The fraction of BA patients with the reduced physical development is increased monotonically and significantly when the BA severity increases: healthy group, 8.2% (72/875), BA intermittent, 4.2% (6/144), BA mild persistent 9% (47/520), BA moderate persistent, 11.7% (36/308), and BA severe persistent, 24.3% (17/70) ( = 45.6, = 0,0009). . The fraction of the children with the reduced height is increased monotonically and significantly in the groups of increasing BA severities. At the same time, the fraction of such children in groups of intermittent and mild persistent BA practically does not differ from the conditionally healthy peers.
评估了支气管哮喘 (BA) 严重程度对儿童患者体格发育的影响,并与健康人群进行了比较。评估了 1042 名患有特应性 BA 的儿童和青少年(768 名男孩)。所有儿童均在临床环境中接受了标准检查,包括人体测量学检查。对照组包括 875 名年龄相近的健康儿童(423 名男孩)。在整个 BA 患者群体中,正常、较低和较高身高的患者比例接近健康人群中的相应值(=3.32,=0.65)。当 BA 严重程度增加时,身体发育不良的 BA 患者比例呈单调递增且显著增加:健康组为 8.2%(72/875),间歇性 BA 为 4.2%(6/144),轻度持续性 BA 为 9%(47/520),中度持续性 BA 为 11.7%(36/308),严重持续性 BA 为 24.3%(17/70)(=45.6,=0.0009)。在 BA 严重程度逐渐增加的各组中,身高较低的儿童比例呈单调递增且显著增加。同时,在间歇性和轻度持续性 BA 组中,这类儿童的比例与条件健康同龄人基本没有差异。