Sánchez-García Silvia, Habernau Mena Alicia, Quirce Santiago
Allergy Section, Hospital Infantil Universitario Niño Jesús and Health Research Institute La Princesa, Madrid, Spain.
Allergy Section, Hospital de Mérida, Badajoz, Spain.
Eur Clin Respir J. 2017 Aug 9;4(1):1356160. doi: 10.1080/20018525.2017.1356160. eCollection 2017.
Asthma is a common disease in both high and lower income countries that starts early and persists often for life. A correct and accurate diagnosis, treatment and follow-up during childhood are essential for a better understanding of adult asthma and avoiding over- or under-treatment. Th2 inflammation in children with asthma symptoms is usually assessed by measuring with serum total IgE, blood eosinophilia and FeNO levels that may help to predict asthma, particularly in those infants and young children in whom lung function tests are difficult to perform. FeNO measurement, compared to intra-individual levels, may be useful also for ascertaining treatment adherence. Nevertheless, an isolated measurement may be insufficient and only the combination of these markers improves the diagnosis, phenotyping and follow-up of an asthmatic child.
哮喘在高收入和低收入国家都是一种常见疾病，发病早且常常持续终生。儿童期进行正确、准确的诊断、治疗和随访对于更好地了解成人哮喘以及避免过度治疗或治疗不足至关重要。哮喘症状儿童的Th2炎症通常通过检测血清总IgE、血液嗜酸性粒细胞和呼出气一氧化氮（FeNO）水平来评估，这些指标可能有助于预测哮喘，特别是对于那些难以进行肺功能测试的婴幼儿。与个体内水平相比，FeNO测量对于确定治疗依从性也可能有用。然而，单一测量可能不够，只有这些标志物的组合才能改善哮喘儿童的诊断、表型分析和随访。
