内质网-内溶酶体接触位点在疾病中的发现及作用
Discovery and Roles of ER-Endolysosomal Contact Sites in Disease.
作者信息
Henne William Mike
机构信息
Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, 75013, USA.
出版信息
Adv Exp Med Biol. 2017;997:135-147. doi: 10.1007/978-981-10-4567-7_10.
Abstract
Inter-organelle membrane contact sites (MCSs) serve as unique microenvironments for the sensing and exchange of cellular metabolites and lipids. Though poorly defined, ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making. Here, we review the discovery and current state of knowledge of ER-endolysosomal MCSs with particular focus on the molecular players that establish and/or utilize these contact sites in metabolism. We also discuss associations of ER-endolysosomal MCS-associated proteins in human disease, as well as the therapeutic promise these contact sites hold in modulating cellular physiology.
摘要
细胞器间膜接触位点（MCSs）作为细胞代谢物和脂质感知与交换的独特微环境。尽管定义尚不明确，但内质网-内溶酶体接触位点正迅速被视为细胞器间脂质交换和代谢决策的中心。在此，我们回顾内质网-内溶酶体MCSs的发现及当前的知识状态，特别关注在代谢中建立和/或利用这些接触位点的分子参与者。我们还讨论了内质网-内溶酶体MCS相关蛋白与人类疾病的关联，以及这些接触位点在调节细胞生理方面的治疗前景。
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