Alves Erika P, de F Lima Rennaly, de Almeida Carolina M, Freires Irlan A, Rosalen Pedro L, Ruiz Ana Ltg, Granville-Garcia Ana F, Godoy Gustavo P, Pereira Jozinete V, de Brito Costa Edja Mm
Department of Dentistry, Paraiba State University Campina Grande, Paraiba, Brazil.
Department of Physiological Science, University of Campinas Piracicaba, Sao Paulo, Brazil.
J Contemp Dent Pract. 2017 Aug 1;18(8):635-640. doi: 10.5005/jp-journals-10024-2098.
Bauhinia forficata and Cnidoscolus quercifolius plants are commonly used in folk medicine. However, few studies have investigated their therapeutic potential.
Herein, we evaluated the antimicrobial activity of B. forficata and C. quercifolius extracts against microorganisms of clinical relevance and their antiproliferative potential against tumor cells.
The following tests were performed: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC), inhibition of biofilm adhesion, and effects on cell morphology. Antiproliferative tests were carried out with human keratinocytes and six tumor lines.
Bauhinia forficata showed antimicrobial activity only against C. albicans with MIC of 15.62 ug/mL and MFC higher than 2000 ug/mL. It also inhibited biofilm adhesion and caused alterations in cell morphology. Cnidoscolus quercifolius showed no significant activity (MIC > 2.0 mg/mL) against the strains. Bauhinia forficata and C. quercifolius extracts showed cytostatic activity against the tumor cells.
Bauhinia forficata has promising anti-Cand/da activity and should be further investigated for its therapeutic potential.
The use of medicinal plants in the treatment of infectious processes has an important function nowadays, due to the limitations of the use of synthetic antibiotics available, related specifically to the microbial resistance emergence.
紫铆和栎叶刺荨麻植物常用于民间医学。然而，很少有研究调查它们的治疗潜力。
在此，我们评估了紫铆和栎叶刺荨麻提取物对具有临床相关性的微生物的抗菌活性及其对肿瘤细胞的抗增殖潜力。
进行了以下测试：最低抑菌浓度（MIC）和最低杀菌浓度（MBC）/最低杀真菌浓度（MFC）、生物膜粘附抑制以及对细胞形态的影响。用人角质形成细胞和六种肿瘤细胞系进行抗增殖测试。
紫铆仅对白色念珠菌具有抗菌活性，MIC为15.62微克/毫升，MFC高于2000微克/毫升。它还抑制生物膜粘附并导致细胞形态改变。栎叶刺荨麻对这些菌株没有显著活性（MIC>2.0毫克/毫升）。紫铆和栎叶刺荨麻提取物对肿瘤细胞显示出细胞生长抑制活性。
紫铆具有有前景的抗白色念珠菌活性，其治疗潜力应进一步研究。
由于现有合成抗生素使用的局限性，特别是与微生物耐药性的出现有关，药用植物在治疗感染过程中具有重要作用。
