Fernandes Anna Flávia Costa, Silvestre Geovana Ferreira Guedes, Rocha Júnior Antônio Carlos Santos, de Souza Lima Tatjana Keesen, Ruiz Ana Lúcia Tasca Gois, Alves Harley da Silva
Post-Graduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Brazil.
Department of Cellular and Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.
Nat Prod Res. 2021 Dec;35(23):5339-5343. doi: 10.1080/14786419.2020.1758089. Epub 2020 Apr 27.
is an Euphorbiaceae endemic to the northeast region of Brazil, which is used in folk medicine as anti-inflammatory, analgesic and antibiotic. An ethanolic extract was prepared with the leaves from , and also partitioned and chromatographed leading to the isolation of cyanoglucoside linamarin (), cinnamic acid (), as well as a mixture of steroids and terpenoids (). Structural elucidation of the compounds was done by IR, MS and NMR analysis. For the cyanoglucoside () were also evaluated its antimicrobial and antileishmanial viabilities by plaque microdilution and MTT test, respectively. Both tests showed from moderate to zero activity against the organisms evaluated. In addition, the antiproliferative activity of compounds and were tested against tumor cells, which did not show statistically significant growth inhibition 50% (GI). The obtained results suggested that further pharmacological studies should prove the folk medicinal uses.
