Bataini J P, Chavanne G, Brugere J, Mazabraud A
Rev Stomatol Chir Maxillofac. 1979;80(3):178-82.
Radiation-induced cancers are fortunately a very rare complication of radiotherapy for cancers. Sagerman, however, reported 21 cases in a series of 243 patients with retinoblastomas, examined after a period of at least 5 years, and 6 cases were observed in a similar series of 112 children seen at the Curie Institute. This report describes 10 cases of irradiation-induced cancers of the maxillofacial region seen at the Curie Institute over a period of 30 years. The exceptional nature of this risk is such that it cannot represent a contra-indication to irradiation therapy of a malignant tumor, especially now that low-energy radiation has been abandoned, and with the modern therapeutic procedures available. The risks of cancer are greater, however, after irradiation of benign bone lesions and benign affections of the cervico-facial region. Treatment of these benign affections in children or young adults by low or reduced doses of conventional low-energy radiations should be forbidden, and the indication for treatment with radiations, which must be of high voltage, should be exceptional.
幸运的是，放射性癌症是癌症放射治疗中非常罕见的并发症。然而，萨格曼报告称，在一系列243例视网膜母细胞瘤患者中，经过至少5年的观察期后发现了21例此类病例；在居里研究所就诊的112名儿童的类似系列病例中，观察到6例。本报告描述了居里研究所在30年期间发现的10例颌面区域辐射诱发癌症病例。这种风险的特殊性在于，它不能成为恶性肿瘤放射治疗的禁忌症，特别是现在低能辐射已被摒弃，且有了现代治疗手段。然而，在照射良性骨病变和颈面部良性疾病后，患癌症的风险更大。应禁止对儿童或年轻人的这些良性疾病采用低剂量或减少剂量的传统低能辐射进行治疗，且必须使用高电压辐射进行治疗的指征应极为罕见。
