Savage A P, Matthews J L, Adrian T E, Ghatei M A, Cooke T, Bloom S R
Carcinogenesis. 1987 Apr;8(4):561-3. doi: 10.1093/carcin/8.4.561.
The effect of daily parenteral administration of a long-acting analogue of somatostatin (SMS 201-995) on the development of intestinal tumours and the rate of crypt cell proliferation in azoxymethane-treated rats has been studied. SMS 201-995 had no significant effect on the number of colonic tumours induced. In the duodenum, SMS 201-995 administration was associated with a change in the number of tumours from 1.4/rat in saline-treated animals to 2.4/rat in animals treated for the last third of the study and 2.8/rat in animals treated with SMS for the entire duration of the study (P less than 0.02). SMS had no significant effect on the rate of cell proliferation in the duodenum, ileum or colon. The inhibition of release of gastrointestinal trophic hormones by this analogue of somatostatin thus does not appear to reduce the number of tumours in the intestine of azoxymethane-treated rats.
研究了每日经肠胃外给予长效生长抑素类似物（SMS 201-995）对用偶氮甲烷处理的大鼠肠道肿瘤发生及隐窝细胞增殖速率的影响。SMS 201-995对诱发的结肠肿瘤数量无显著影响。在十二指肠中，给予SMS 201-995后，肿瘤数量发生了变化，从盐水处理动物的1.4个/大鼠，在研究最后三分之一时间接受处理的动物中变为2.4个/大鼠，在整个研究期间接受SMS处理的动物中为2.8个/大鼠（P<0.02）。SMS对十二指肠、回肠或结肠中的细胞增殖速率无显著影响。因此，这种生长抑素类似物对胃肠营养激素释放的抑制作用似乎并未减少用偶氮甲烷处理的大鼠肠道中的肿瘤数量。
