Mooney S M, Loretz C A
Comp Biochem Physiol A Comp Physiol. 1987;86(2):367-72. doi: 10.1016/0300-9629(87)90344-6.
The effects of a dihydroxy and a trihydroxy bile salt on the Na+- and Cl(-)-absorbing, goby posterior intestine are quite different. Taurochenodeoxycholate, a dihydroxy bile salt, increases tissue permeability to Cl-, primarily by opening the paracellular shunt pathway. The trihydroxy bile salt taurocholate lacks these effects and may, in fact, decrease tissue permeability. In light of the general structural similarity of these two molecules, a detergent action is considered unlikely and, instead, a more specific (perhaps receptor-mediated) mechanism is suggested.
二羟基和三羟基胆汁盐对虎鱼后肠中钠和氯吸收的影响截然不同。二羟基胆汁盐牛磺鹅去氧胆酸盐主要通过打开细胞旁分流途径，增加组织对氯的通透性。三羟基胆汁盐牛磺胆酸盐则没有这些作用，实际上可能会降低组织通透性。鉴于这两种分子在结构上的总体相似性，不太可能是去污剂作用，相反，有人提出了一种更具特异性（可能是受体介导）的机制。
