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本文引用的文献

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Efficacy of oral pre-exposure prophylaxis (PrEP) for HIV among women with abnormal vaginal microbiota: a post-hoc analysis of the randomised, placebo-controlled Partners PrEP Study.口服暴露前预防(PrEP)对阴道微生态异常女性中 HIV 有效性的影响:随机、安慰剂对照的 Partners PrEP 研究的事后分析。
Lancet HIV. 2017 Oct;4(10):e449-e456. doi: 10.1016/S2352-3018(17)30110-8. Epub 2017 Jul 18.
2
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.阴道细菌会降低非洲女性使用替诺福韦艾滋病微凝胶的疗效。
Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.
3
Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.缺乏乳酸杆菌的宫颈阴道细菌群落与南非年轻女性感染艾滋病毒的风险增加有关。
Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.
4
Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.宫颈阴道炎症促进感染性较低的HIV变体的获得。
Clin Infect Dis. 2017 Jan 1;64(1):79-82. doi: 10.1093/cid/ciw663. Epub 2016 Sep 29.
5
HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities.撒哈拉以南非洲地区的艾滋病毒感染与艾滋病:现状、挑战与机遇
Open AIDS J. 2016 Apr 8;10:34-48. doi: 10.2174/1874613601610010034. eCollection 2016.
6
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.女性生殖道中炎症细胞因子水平升高与蛋白酶、黏膜屏障蛋白的表达改变以及HIV易感靶细胞的流入有关。
Mucosal Immunol. 2016 Jan;9(1):194-205. doi: 10.1038/mi.2015.51. Epub 2015 Jun 24.
7
Genital inflammation and the risk of HIV acquisition in women.女性生殖器炎症与感染艾滋病毒的风险
Clin Infect Dis. 2015 Jul 15;61(2):260-9. doi: 10.1093/cid/civ298. Epub 2015 Apr 21.
8
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.替诺福韦凝胶作为一种抗逆转录病毒的杀微生物剂,用于预防女性感染艾滋病毒的有效性和安全性。
Science. 2010 Sep 3;329(5996):1168-74. doi: 10.1126/science.1193748. Epub 2010 Jul 19.
9
Vaginal microbiome of reproductive-age women.育龄期女性的阴道微生物组。
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1(Suppl 1):4680-7. doi: 10.1073/pnas.1002611107. Epub 2010 Jun 3.
10
Intravaginal practices, bacterial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanisms.阴道内性行为、细菌性阴道病与女性对HIV感染的易感性:流行病学证据及生物学机制
Lancet Infect Dis. 2005 Dec;5(12):786-94. doi: 10.1016/S1473-3099(05)70298-X.

细菌、药物与 HIV:阴道微生物组在 HIV 风险和抗逆转录病毒预防 HIV 疗效中的作用。

Bugs, drugs, and HIV: the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention.

机构信息

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Genome Med. 2017 Aug 17;9(1):74. doi: 10.1186/s13073-017-0469-2.

DOI:10.1186/s13073-017-0469-2
PMID:28818087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5561602/
Abstract

Advances in molecular tools to characterize the microbiome have led to the discovery of unique roles for microbes in human disease. Findings that the female genital microbiome can influence HIV acquisition and prevention emphasize the importance of microbiome analysis in clinical trials that assess the efficacy of HIV prevention interventions.

摘要

分子工具的进步使人们能够深入了解微生物组,从而发现微生物在人类疾病中的独特作用。研究发现,女性生殖道微生物组可以影响 HIV 的感染和预防,这强调了在评估 HIV 预防干预措施效果的临床试验中进行微生物组分析的重要性。