HIV感染和抗逆转录病毒治疗背景下肠道微生物群失调的复杂性
Complexities of Gut Microbiome Dysbiosis in the Context of HIV Infection and Antiretroviral Therapy.
作者信息
Li S X, Armstrong Ajs, Neff C P, Shaffer M, Lozupone C A, Palmer B E
机构信息
Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.
Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.
出版信息
Clin Pharmacol Ther. 2016 Jun;99(6):600-11. doi: 10.1002/cpt.363. Epub 2016 Apr 16.
Abstract
Human immunodeficiency virus (HIV) infection is associated with an altered gut microbiome that is not consistently restored with effective antiretroviral therapy (ART). Interpretation of the specific microbiome changes observed during HIV infection is complicated by factors like population, sample type, and ART-each of which may have dramatic effects on gut bacteria. Understanding how these factors shape the microbiome during HIV infection (which we refer to as the HIV-associated microbiome) is critical for defining its role in HIV disease, and for developing therapies that restore gut health during infection.
摘要
人类免疫缺陷病毒（HIV）感染与肠道微生物群的改变有关，即使采用有效的抗逆转录病毒疗法（ART），这种改变也不能持续恢复。HIV感染期间观察到的特定微生物群变化的解释因人群、样本类型和ART等因素而变得复杂，其中每一个因素都可能对肠道细菌产生显著影响。了解这些因素如何在HIV感染期间塑造微生物群（我们称之为HIV相关微生物群）对于确定其在HIV疾病中的作用以及开发在感染期间恢复肠道健康的疗法至关重要。
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