短期中度睡眠限制降低年轻健康成年人的胰岛素敏感性。
Short-Term Moderate Sleep Restriction Decreases Insulin Sensitivity in Young Healthy Adults.
机构信息
Exercise Science, University of South Carolina, Columbia, SC, USA.
Exercise Science, University of South Carolina, Columbia, SC, USA.
出版信息
Sleep Health. 2016 Mar;2(1):63-68. doi: 10.1016/j.sleh.2015.11.004.
CONTEXT AND PURPOSE
The literature suggests that severe sleep loss of more than a few hours a night decreases glucose tolerance and insulin sensitivity. The aim of this study was to determine whether moderate sleep restriction had similar effects.
METHODS
Fifteen healthy non-obese (BMI=24.5±3.4 kg/m) young adults (20.6±1.3 years) completed two 2-hour oral glucose tolerance tests (OGTT): one was after 3 days of time-in-bed restriction by 1-3 hours each night, and the other was after 3 days of ad libitum sleep. Glucose and insulin concentrations during OGTT, and fasting glucagon and cortisol concentrations were determined. The homeostasis model of insulin resistance (HOMA-IR), Matsuda index, and the quantitative insulin sensitivity check index (QUICKI) were calculated.
RESULTS
The total time-in-bed during the sleep restriction and the ad libitum phase was 5.98±0.76 and 7.98±0.54 hours/day, and total sleep time was 5.16±0.49 and 6.65±0.64 hours/day, respectively. Glucose concentrations before and 30, 60, 90, and 120 minutes following consumption of glucose and area under the curve were not different for the two OGTT (p > 0.10 for all). Insulin concentration at fasting and area under the curve during the OGTT were significantly higher (p = 0.034 and 0.038, respectively) following restricted sleep than following ad libitum sleep. Fasting glucagon concentration was also higher (p = 0.003). The HOMA-IR, Matsuda index, and QUICKI all suggested decreased insulin sensitivity following restricted sleep.
CONCLUSION
Short-term moderate sleep restriction reduced insulin sensitivity compared to ad libitum sleep in this group of healthy young adults.
背景和目的
文献表明，每晚超过几个小时的严重睡眠不足会降低葡萄糖耐量和胰岛素敏感性。本研究的目的是确定适度的睡眠限制是否具有类似的影响。
方法
15 名健康的非肥胖（BMI=24.5±3.4kg/m）年轻人（20.6±1.3 岁）完成了两次 2 小时口服葡萄糖耐量试验（OGTT）：一次是在每晚限制 1-3 小时的睡眠时间后 3 天，另一次是在自由睡眠后 3 天。OGTT 期间测定血糖和胰岛素浓度，以及空腹胰高血糖素和皮质醇浓度。计算胰岛素抵抗的稳态模型（HOMA-IR）、Matsuda 指数和定量胰岛素敏感性检查指数（QUICKI）。
结果
睡眠限制和自由睡眠期间的总卧床时间分别为 5.98±0.76 和 7.98±0.54 小时/天，总睡眠时间分别为 5.16±0.49 和 6.65±0.64 小时/天。两次 OGTT 前后的血糖浓度以及 30、60、90 和 120 分钟的血糖曲线下面积均无差异（p>0.10）。与自由睡眠相比，限制睡眠后空腹胰岛素浓度和 OGTT 期间的曲线下面积明显更高（p=0.034 和 0.038）。空腹胰高血糖素浓度也较高（p=0.003）。HOMA-IR、Matsuda 指数和 QUICKI 均提示限制睡眠后胰岛素敏感性降低。
结论
与自由睡眠相比，该组健康年轻成年人短期适度睡眠限制会降低胰岛素敏感性。
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