Diabetes and Metabolic Medicine, University of Surrey, Guildford GU2 7WG, UK.
Metabolism. 2013 Feb;62(2):204-11. doi: 10.1016/j.metabol.2012.07.016. Epub 2012 Sep 15.
Evidence for a causal relationship between sleep-loss and metabolism is derived primarily from short-term sleep deprivation studies in the laboratory. The objective of this study was to investigate whether small changes in sleep duration over a three week period while participants are living in their normal environment lead to changes in insulin sensitivity and other metabolic parameters.
Nineteen healthy, young, normal-weight men were randomised to either sleep restriction (habitual bedtime minus 1.5h) or a control condition (habitual bedtime) for three weeks. Weekly assessments of insulin sensitivity by hyperinsulinaemic-euglycaemic clamp, anthropometry, vascular function, leptin and adiponectin were made. Sleep was assessed continuously using actigraphy and diaries.
Assessment of sleep by actigraphy confirmed that the intervention reduced daily sleep duration by 01:19 ± 00:15 (SE; p<0.001). Sleep restriction led to changes in insulin sensitivity, body weight and plasma concentrations of leptin which varied during the three week period. There was no effect on plasma adiponectin or vascular function.
Even minor reductions in sleep duration lead to changes in insulin sensitivity, body weight and other metabolic parameters which vary during the exposure period. Larger and longer longitudinal studies of sleep restriction and sleep extension are warranted.
睡眠不足与新陈代谢之间存在因果关系的证据主要来自于实验室中的短期睡眠剥夺研究。本研究旨在探讨在正常环境下生活的三周内，睡眠时间的微小变化是否会导致胰岛素敏感性和其他代谢参数的变化。
19 名健康、年轻、体重正常的男性被随机分配至睡眠限制（习惯睡眠时间减去 1.5 小时）或对照条件（习惯睡眠时间）组，持续 3 周。每周通过高胰岛素-正葡萄糖钳夹法评估胰岛素敏感性，同时进行人体测量学、血管功能、瘦素和脂联素检测。使用活动记录仪和日记连续评估睡眠。
活动记录仪评估的睡眠结果证实，干预使每日睡眠时间减少了 01:19 ± 00:15（标准误差；p<0.001）。睡眠限制导致胰岛素敏感性、体重和瘦素血浆浓度发生变化，且这些变化在 3 周期间有所波动。脂联素或血管功能无变化。
即使睡眠时间略有减少，也会导致胰岛素敏感性、体重和其他代谢参数发生变化，且这些变化会在暴露期间发生波动。需要进行更大规模和更长时间的睡眠限制和延长研究。
