Tabor E
J Med Virol. 1987 Mar;21(3):207-16. doi: 10.1002/jmv.1890210303.
Guillain-Barré syndrome and other neurologic syndromes occur rarely as complications of viral hepatitis, although a causal association has not been established. Seven cases of serologically documented hepatitis A have been reported with Guillain-Barré syndrome; all recovered, with mild neurologic residua in four. Eight cases of serologically documented acute hepatitis B have been reported with Guillain-Barré syndrome; all recovered, with mild neurologic residua in two. In one case, immune complexes of hepatitis B surface antigen and its antibody were present in the cerebrospinal fluid. Other neurologic syndromes have also been reported in patients with serologically defined viral hepatitis, including mononeuritis, auditory neuritis, and seizures. Chronic hepatitis B and mononeuritis multiplex are found together in 31-54% of patients with periarteritis nodosa. The mechanisms for these associations are unknown, but may include direct cytotoxicity of the virus or immune-mediated damage. Vasculitis of the vasa nervorum plays an intermediate role in at least some cases.
吉兰 - 巴雷综合征和其他神经综合征作为病毒性肝炎的并发症很少见，尽管尚未确立因果关系。已有7例血清学确诊为甲型肝炎的患者并发吉兰 - 巴雷综合征的报道；所有患者均康复，4例有轻度神经后遗症。已有8例血清学确诊为急性乙型肝炎的患者并发吉兰 - 巴雷综合征的报道；所有患者均康复，2例有轻度神经后遗症。有1例患者脑脊液中存在乙型肝炎表面抗原及其抗体的免疫复合物。血清学确诊的病毒性肝炎患者还出现过其他神经综合征，包括单神经炎、听神经炎和癫痫发作。在结节性多动脉炎患者中，31% - 54%同时存在慢性乙型肝炎和多发性单神经炎。这些关联的机制尚不清楚，但可能包括病毒的直接细胞毒性或免疫介导的损伤。至少在某些病例中，神经滋养血管的血管炎起了中间作用。
