Sonavane Amey Dilip, Saigal Sanjiv, Kathuria Abhishek, Choudhary Narendra S, Saraf Neeraj
Department of Liver Transplantation and Regenerative Medicine, Medanta - the Medicity, 14th Floor, Gurugram, 122001, India.
Clin J Gastroenterol. 2018 Aug;11(4):312-314. doi: 10.1007/s12328-018-0847-3. Epub 2018 Mar 14.
Extrahepatic syndromes are uncommon manifestations of acute and chronic hepatitis B. The pathogenesis likely involves an aberrant immunologic response to extrahepatic viral proteins. Antiviral therapy reduces the availability of these viral protein antigens and thus halts immune activation. Approximately 1% of all cases of acute inflammatory demyelinating polyneuropathy are associated with hepatitis B. Guillain-Barre syndrome (GBS) is a remarkably clinically diverse disorder with distinctive variants characterised by an immune-mediated attack to components of the peripheral nervous system. In this report, we present a rare case of GBS with chronic hepatitis B that resolved with antiviral and intravenous immunoglobulin therapy.
肝外综合征是急慢性乙型肝炎的罕见表现。其发病机制可能涉及对肝外病毒蛋白的异常免疫反应。抗病毒治疗可减少这些病毒蛋白抗原的产生,从而停止免疫激活。急性炎性脱髓鞘性多发性神经病的所有病例中约有1%与乙型肝炎有关。吉兰-巴雷综合征(GBS)是一种临床症状极为多样的疾病,具有独特的变异型,其特征是免疫介导的对周围神经系统成分的攻击。在本报告中,我们介绍了一例罕见的慢性乙型肝炎合并GBS的病例,该病例通过抗病毒和静脉注射免疫球蛋白治疗得以缓解。