Penner E, Maida E, Mamoli B, Gangl A
Gastroenterology. 1982 Mar;82(3):576-80.
A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-complex material with recovery. Our data indicate that these immune complexes in cerebrospinal fluid reflect leakage from the systemic circulation via a deranged blood-brain barrier and are not generated in the cerebrospinal compartment. Possibly deposition of such immune complexes along nerve structures is important in the immunopathogenesis of some cases of Guillain-Barré syndrome.
一名76岁男性在急性乙型肝炎病毒感染后出现格林-巴利综合征。主要免疫学特征为：(a) 在急性神经综合征期间，血清和脑脊液中循环的含乙型肝炎表面抗原免疫复合物水平升高；(b) 随着病情恢复，免疫复合物物质清除。我们的数据表明，脑脊液中的这些免疫复合物反映了通过紊乱的血脑屏障从体循环渗漏而来，而非在脑脊液腔室中产生。此类免疫复合物沿神经结构的沉积可能在某些格林-巴利综合征病例的免疫发病机制中起重要作用。
