Gaudin R A, Hoehle L P, Birkelbach M-A, Phillips K M, Beule A G, Caradonna D S, Gray S T, Sedaghat A R
Klinik für Mund- Kiefer- und Plastische Gesichtschirurgie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, 02114, Boston, MA, USA.
HNO. 2017 Dec;65(12):987-992. doi: 10.1007/s00106-017-0398-9.
Allergic rhinitis (AR) is the most common form of atopic disease, comprising 50% of atopic diseases. Recently, this disease has increasingly been the focus of intensive research. Previous work has shown that AR has a significant impact on sleep quality. To date there are no published studies demonstrating a quantitative association between the extent of control of AR and the severity of compromised sleep quality.
Patients with AR were prospectively recruited into our cross-sectional study. Sleep quality was assessed using five of the sleep subdomain questions from the 22-item Sinonasal Outcome Test (SNOT-22). Control of AR was assessed using the Rhinitis Control Assessment Test (RCAT). Association was sought between the degree of allergic rhinitis control (RCAT) as independent variable and sleep quality as dependent variable using linear regression.
A total of 104 patients (54.8% female and 45.2% male) with an average age of 41.4 years (SD: 15.9 years) were included in the study. There were statistically significant associations between the RCAT score and the score of each of the five SNOT-22 questions used to assess decreased sleep quality (p < 0.001). These associations remained significant (p < 0.001) even after controlling participants' clinical and demographic characteristics.
This is the first study showing that level of control of AR correlates with the severity of subjectively perceived sleep quality detriment. These results indicate that an improvement in AR control could lead to improved subjective sleep quality but a prospective interventional study is needed to confirm these results.
变应性鼻炎（AR）是最常见的特应性疾病形式，占特应性疾病的50%。近年来，该疾病日益成为深入研究的焦点。既往研究表明，AR对睡眠质量有显著影响。迄今为止，尚无已发表的研究证明AR的控制程度与睡眠质量受损的严重程度之间存在定量关联。
前瞻性招募AR患者纳入我们的横断面研究。使用22项鼻鼻窦结局测试（SNOT-22）中的5个睡眠子领域问题评估睡眠质量。使用鼻炎控制评估测试（RCAT）评估AR的控制情况。以变应性鼻炎控制程度（RCAT）为自变量，睡眠质量为因变量，采用线性回归分析二者之间的关联。
本研究共纳入104例患者（女性54.8%，男性45.2%），平均年龄41.4岁（标准差：15.9岁）。RCAT评分与用于评估睡眠质量下降的5个SNOT-22问题中的每一个问题的评分之间存在统计学显著关联（p < 0.001）。即使在控制了参与者的临床和人口统计学特征后，这些关联仍然显著（p < 0.001）。
这是第一项表明AR的控制水平与主观感知的睡眠质量损害严重程度相关的研究。这些结果表明，改善AR的控制可能会改善主观睡眠质量，但需要进行前瞻性干预研究来证实这些结果。
