Nima Maisha Khair, Hougard Thomas, Hossain Mohammad Enayet, Kibria Mohammad Golam, Mohon Abu Naser, Johora Fatema Tuj, Rahman Rajibur, Haque Rashidul, Alam Mohammad Shafiul
International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Am J Trop Med Hyg. 2017 Oct;97(4):1155-1158. doi: 10.4269/ajtmh.16-0884. Epub 2017 Aug 18.
Several species of are responsible for causing malaria in humans. Proper diagnoses are crucial to case management, because severity and treatment varies between species. Diagnoses can be made using rapid diagnostic tests (RDTs), which detect proteins. causes the most virulent cases of malaria, and histidine-rich protein 2 (PfHRP2) is a common target of falciparum malaria RDTs. Here we report a case in which a falciparum malaria patient in Bangladesh tested negative on PfHRP2-based RDTs. The negative results can be attributed to a deletion of part of the gene and frameshift mutations in both and gene. This finding may have implications for malaria diagnostics and case management in Bangladesh and other regions of South Asia.
几种疟原虫可导致人类患疟疾。准确诊断对于病例管理至关重要，因为不同疟原虫种类导致的病情严重程度和治疗方法有所不同。可使用快速诊断检测（RDT）进行诊断，这种检测能检测疟原虫蛋白质。恶性疟原虫会引发最严重的疟疾病例，富含组氨酸的蛋白质2（PfHRP2）是恶性疟原虫RDT的常见检测靶点。在此，我们报告一例孟加拉国的恶性疟原虫疟疾患者基于PfHRP2的RDT检测呈阴性的病例。阴性结果可能归因于该疟原虫基因部分缺失以及另外两个基因发生移码突变。这一发现可能对孟加拉国及南亚其他地区的疟疾诊断和病例管理产生影响。
