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社区获得性肺炎病因及转归的前瞻性研究。

Prospective study of the aetiology and outcome of pneumonia in the community.

作者信息

Woodhead M A, Macfarlane J T, McCracken J S, Rose D H, Finch R G

出版信息

Lancet. 1987 Mar 21;1(8534):671-4. doi: 10.1016/s0140-6736(87)90430-2.

Abstract

A prospective one-year study of community pneumonia was conducted in Nottingham. 236 of 251 episodes of pneumonia (defined as an acute lower respiratory tract infection, for which antibiotics were prescribed, associated with new focal signs on examination of the chest) were investigated. Acute radiographic changes were present in 93 (39%). A pathogen was identified in 129 (55%) episodes, with Streptococcus pneumoniae, Haemophilus influenzae, and influenza viruses those most frequently identified. Mycoplasma pneumoniae was uncommon and infection with Legionella pneumophila was found in only 1 episode. Hospital admission was required in 52 (22%) episodes. 7 patients died (3%), all but one of the deaths occurring in patients who had been admitted to hospital. Pneumonia in the community is common but few people die of it. Initial antibiotic therapy should always cover S pneumoniae and H influenzae.

摘要

在诺丁汉进行了一项为期一年的社区肺炎前瞻性研究。对251例肺炎发作(定义为急性下呼吸道感染,为此开具了抗生素,胸部检查伴有新的局灶性体征)中的236例进行了调查。93例(39%)出现急性影像学改变。129例(55%)发作中鉴定出病原体,其中肺炎链球菌、流感嗜血杆菌和流感病毒是最常鉴定出的病原体。肺炎支原体不常见,仅在1例发作中发现感染嗜肺军团菌。52例(22%)发作需要住院治疗。7例患者死亡(3%),除1例死亡外,所有死亡均发生在入院患者中。社区肺炎很常见,但很少有人死于该病。初始抗生素治疗应始终覆盖肺炎链球菌和流感嗜血杆菌。

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