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Amyloid and Tau Pathology in Normal Cognitive Aging.

作者信息

Reas Emilie T

机构信息

Department of Radiology, University of California, San Diego, La Jolla, California 92093

出版信息

J Neurosci. 2017 Aug 9;37(32):7561-7563. doi: 10.1523/JNEUROSCI.1388-17.2017.

DOI:10.1523/JNEUROSCI.1388-17.2017
PMID:28821682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6596650/
Abstract
摘要

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本文引用的文献

1
Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging.在正常衰老过程中，tau蛋白和β-淀粉样蛋白与内侧颞叶结构、功能及记忆编码相关。
J Neurosci. 2017 Mar 22;37(12):3192-3201. doi: 10.1523/JNEUROSCI.3769-16.2017. Epub 2017 Feb 17.
2
Sparse and distributed coding of episodic memory in neurons of the human hippocampus.人类海马体神经元中情景记忆的稀疏和分布式编码。
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9621-6. doi: 10.1073/pnas.1408365111. Epub 2014 Jun 16.
3
What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus.正常衰老中有哪些正常现象？衰老、淀粉样蛋白和阿尔茨海默病对大脑皮层和海马体的影响。
Prog Neurobiol. 2014 Jun;117:20-40. doi: 10.1016/j.pneurobio.2014.02.004. Epub 2014 Feb 16.
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Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment.海马活动亢进的减轻可改善遗忘型轻度认知障碍的认知功能。
Neuron. 2012 May 10;74(3):467-74. doi: 10.1016/j.neuron.2012.03.023.
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Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease.在阿尔茨海默病患者中，与从轻度认知障碍向痴呆快速进展相关的是损伤标志物，而不是淀粉样蛋白标志物。
J Alzheimers Dis. 2012;29(2):319-27. doi: 10.3233/JAD-2011-111694.
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Neuronal activity regulates the regional vulnerability to amyloid-β deposition.神经元活动调节淀粉样β沉积的区域易感性。
Nat Neurosci. 2011 Jun;14(6):750-6. doi: 10.1038/nn.2801. Epub 2011 May 1.
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Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults.非痴呆老年人大脑中海马 CA3 和齿状回活动增加与模式分离缺陷相关。
Hippocampus. 2011 Sep;21(9):968-79. doi: 10.1002/hipo.20808. Epub 2010 May 20.
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Individual differences in spatial pattern separation performance associated with healthy aging in humans.个体在空间模式分离表现上的差异与人类健康衰老有关。
Learn Mem. 2010 May 21;17(6):284-8. doi: 10.1101/lm.1768110. Print 2010 Jun.
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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.在阿尔茨海默病小鼠模型中，淀粉样斑块附近的高活性神经元簇。
Science. 2008 Sep 19;321(5896):1686-9. doi: 10.1126/science.1162844.
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The relationship between aging, performance, and the neural correlates of successful memory encoding.衰老、记忆表现与成功记忆编码的神经关联之间的关系。
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