Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO, Valencia, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Sci Total Environ. 2018 Jan 1;610-611:741-749. doi: 10.1016/j.scitotenv.2017.08.042. Epub 2017 Aug 17.
Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005). Infant neuropsychological development was assessed around 12months of age by the Bayley Scales of Infant Development. Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation. Se was measured in serum samples at the first trimester. The mean serum Se concentration was 79.7 (standard deviation=7.9) μg/L. In multivariate analysis, nonsignificant inverse linear associations were found between Se concentrations and standardized mental and psychomotor development scores (β (95% CI)=-0.13 (-0.29, 0.03) and β (95% CI)=-0.08 (-0.24, 0.07), respectively). Generalized additive models indicated inverted U-shaped relationships between Se concentrations and both scales. Using segmented regression, the turning point for the associations was estimated at 86μg/L for both scales. The association between Se and neuropsychological development was inverted U-shaped for children with the AG+AA genotype for rs6970396 INMT but a descending curve was suggested for the GG genotype. Further studies would be necessary in order to disentangle the complex equilibrium between the toxicity and benefits of Se exposure during the prenatal period.
硒（Se）与生命早期的神经发育呈正相关。然而，其安全边际相当狭窄，很少有前瞻性研究评估其在中等水平下的潜在神经毒性作用。我们旨在探索母体硒浓度与儿童神经心理发育之间的关系，包括硒代谢基因 INMT 的遗传效应修饰。研究对象为西班牙儿童与环境项目（INMA，2003-2005 年）中的 650 对母婴。在婴儿 12 个月左右时，通过贝利婴幼儿发育量表评估其神经心理发育。在妊娠第一和第三期，通过问卷收集社会人口统计学和饮食特征。在妊娠第一期测量血清样本中的硒。血清硒浓度的平均值为 79.7（标准差=7.9）μg/L。在多变量分析中，发现硒浓度与标准化精神和运动发育评分之间呈负线性关系（β（95%CI）=-0.13（-0.29，0.03）和β（95%CI）=-0.08（-0.24，0.07））。广义加性模型表明，在两个量表中，硒浓度与两者之间存在倒 U 型关系。使用分段回归，估计出两个量表的转折点均为 86μg/L。对于 rs6970396 INMT 的 AG+AA 基因型的儿童，硒与神经心理发育之间的关系呈倒 U 型，但对于 GG 基因型，提示呈下降曲线。为了阐明产前时期硒暴露的毒性和益处之间的复杂平衡，还需要进一步的研究。
