高维单细胞分析在癌症中的应用。
High-dimension single-cell analysis applied to cancer.
机构信息
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
出版信息
Mol Aspects Med. 2018 Feb;59:70-84. doi: 10.1016/j.mam.2017.08.005. Epub 2017 Aug 30.
Abstract
High-dimension single-cell technology is transforming our ability to study and understand cancer. Numerous studies and reviews have reported advances in technology development. The biological insights gleaned from single-cell technology about cancer biology are less reviewed. Here we focus on research studies that illustrate novel aspects of cancer biology that bulk analysis could not achieve, and discuss the fresh insights gained from the application of single-cell technology across basic and clinical cancer studies.
摘要
高维单细胞技术正在改变我们研究和理解癌症的能力。大量的研究和综述报告了技术发展的进展。单细胞技术对癌症生物学的生物学见解则较少被综述。在这里，我们重点介绍了一些研究，这些研究说明了批量分析无法实现的癌症生物学的新方面，并讨论了单细胞技术在基础和临床癌症研究中的应用所获得的新见解。
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