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含有油酸和棕榈酸的红花籽油通过Notch1增强培养的胚胎神经干细胞的干性并诱导神经元分化。

Safflower Seed Oil, Containing Oleic Acid and Palmitic Acid, Enhances the Stemness of Cultured Embryonic Neural Stem Cells through Notch1 and Induces Neuronal Differentiation.

作者信息

Ghareghani Majid, Zibara Kazem, Azari Hassan, Hejr Hossein, Sadri Farzad, Jannesar Ramin, Ghalamfarsa Ghasem, Delaviz Hamdallah, Nouri Ebrahim, Ghanbari Amir

机构信息

Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical SciencesYasuj, Iran.

ER045, Laboratory of Stem Cells, DSST, Biology Department, Faculty of Sciences, Lebanese UniversityBeirut, Lebanon.

出版信息

Front Neurosci. 2017 Aug 3;11:446. doi: 10.3389/fnins.2017.00446. eCollection 2017.

DOI:10.3389/fnins.2017.00446
PMID:28824367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540893/
Abstract

Embryonic neural stem cells (eNSCs) could differentiate into neurons, astrocytes and oligodendrocytes. This study was aimed to determine the effect of safflower seed oil, which contains linoleic acid (LA), oleic acid (OA), and palmitic acid (PA), on cultured eNSC proliferation and differentiation, in comparison to linoleic acid alone. Results showed that safflower seed oil, but not LA, increased significantly the viability and proliferation of eNSCs. Moreover, treatment of NSCs by safflower seed oil, but not LA, resulted in a significant increase in mRNA levels of notch1, hes1, and Ki-67, and protein levels of notch intracellular domain (NICD), in comparison to controls, indicating an enhancement of stemness. Finally, safflower seed oil, but not LA, caused an increase in the number of oligodendrocytes (MBP+), astrocytes (GFAP+) and neurons (β-III tubulin+) of which only the increase in β-III tubulin positive cells was statistically significant. In summary, OA and PA, present in safflower seed oil may prove beneficial for the enhancement of eNSCs and their neuronal differentiation.

摘要

胚胎神经干细胞（eNSCs）可分化为神经元、星形胶质细胞和少突胶质细胞。本研究旨在确定含有亚油酸（LA）、油酸（OA）和棕榈酸（PA）的红花籽油相较于单独的亚油酸对培养的eNSC增殖和分化的影响。结果显示，红花籽油而非亚油酸显著提高了eNSCs的活力和增殖能力。此外，与对照组相比，用红花籽油而非亚油酸处理神经干细胞导致notch1、hes1和Ki-67的mRNA水平以及notch细胞内结构域（NICD）的蛋白水平显著增加，表明干性增强。最后，红花籽油而非亚油酸导致少突胶质细胞（MBP+）、星形胶质细胞（GFAP+）和神经元（β-III微管蛋白+）数量增加，其中只有β-III微管蛋白阳性细胞的增加具有统计学意义。总之，红花籽油中含有的油酸和棕榈酸可能对增强eNSCs及其神经元分化有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/5b0676be98af/fnins-11-00446-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/cbfa7c859218/fnins-11-00446-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/ec8a586decb2/fnins-11-00446-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/b18ae881691b/fnins-11-00446-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/b1f23c41b7d7/fnins-11-00446-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/5b0676be98af/fnins-11-00446-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/cbfa7c859218/fnins-11-00446-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/ec8a586decb2/fnins-11-00446-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/b18ae881691b/fnins-11-00446-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/b1f23c41b7d7/fnins-11-00446-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1214/5540893/5b0676be98af/fnins-11-00446-g0005.jpg

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