人类嗜T淋巴细胞病毒1型（HTLV-1）的超强致癌性
The Exceptional Oncogenicity of HTLV-1.
作者信息
Tagaya Yutaka, Gallo Robert C
机构信息
Division of Basic Science, Institute of Human Virology, University of Maryland School of MedicineBaltimore, MD, United States.
出版信息
Front Microbiol. 2017 Aug 2;8:1425. doi: 10.3389/fmicb.2017.01425. eCollection 2017.
Abstract
Human T-cell leukemia virus-1 (HTLV-1) is the first pathogenic human retrovirus identified in 1979 by the Gallo group. HTLV-1 causes fatal T-cell leukemia (adult T cell leukemia) and a progressive myelopahy (HTLV-1-associated myelopathy/ tropical spastic paraparesis, HAM/TSP) and other disorders. Since the discovery of HTLV-1, several other microorganisms are demonstrated to cause cancer in humans. In this article, we investigated the oncogenic capacity of HTLV-1, in comparison with those of other oncoviruses and one oncobacterium (Helicobacter pylori, H. Pylori) based on published literature. We conclude here that HTLV-1 is one of the most and may be the most carcinogenic among them and arguably one of the most potent of the known human carcinogens. This fact has not been noted before and is particularly important to justify why we need to study HTLV-1 as an important model of human viral oncogenesis.
摘要
人类T细胞白血病病毒1型（HTLV-1）是1979年由加洛团队鉴定出的第一种致病性人类逆转录病毒。HTLV-1可引发致命的T细胞白血病（成人T细胞白血病）以及一种进行性脊髓病（HTLV-1相关脊髓病/热带痉挛性截瘫，HAM/TSP）和其他疾病。自HTLV-1被发现以来，已证实还有其他几种微生物可导致人类患癌。在本文中，我们基于已发表的文献，将HTLV-1的致癌能力与其他致癌病毒及一种致癌细菌（幽门螺杆菌）进行了比较研究。我们在此得出结论，HTLV-1是其中致癌性最强的病毒之一，甚至可能是最强的，并且可以说是已知人类致癌物中最具致癌力的物质之一。这一事实此前未被注意到，对于解释我们为何需要将HTLV-1作为人类病毒致癌作用的重要模型来研究尤为重要。
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