Masoud Sherry, Lim Phang Boon, Kitas George D, Panoulas Vasileios
Sherry Masoud, Phang Boon Lim, Cardiology Department, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W1 20HS, United Kingdom.
World J Cardiol. 2017 Jul 26;9(7):562-573. doi: 10.4330/wjc.v9.i7.562.
An increased cardiovascular morbidity and mortality, including the risk of sudden cardiac death (SCD), has been shown in patients with rheumatoid arthritis (RA). Abnormalities in autonomic markers such as heart rate variability and ventricular repolarization parameters, such as QTc interval and QT dispersion, have been associated with sudden death in patients with RA. The interplay between these parameters and inflammation that is known to exist with RA is of growing interest. In this article, we review the prevalence and predictors of SCD in patients with RA and describe the potential underlying mechanisms, which may contribute to this. We also review the impact of biologic agents on arrhythmic risk as well as cardiovascular morbidity and mortality.
类风湿关节炎（RA）患者已出现心血管发病率和死亡率增加，包括心源性猝死（SCD）风险。自主神经标志物异常，如心率变异性，以及心室复极参数，如QTc间期和QT离散度，均与RA患者的猝死有关。这些参数与已知存在于RA中的炎症之间的相互作用越来越受到关注。在本文中，我们回顾了RA患者SCD的患病率和预测因素，并描述了可能导致此情况的潜在机制。我们还回顾了生物制剂对心律失常风险以及心血管发病率和死亡率的影响。
