a Institute of Biomedical Sciences, Department of Physiology and Biophysics, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
b Institute of Health Sciences, Department of Nutrition, Federal University of Triângulo Mineiro, Uberaba, MG, 38025-440, Brazil.
Appl Physiol Nutr Metab. 2017 Dec;42(12):1341-1346. doi: 10.1139/apnm-2017-0435. Epub 2017 Aug 21.
Intermittent fasting protocol (IFP) has been suggested as a strategy to change body metabolism and improve health. The effects of IFP seem to be similar to aerobic exercise, having a hormetic adaptation according to intensity and frequency. However, the effects of combining both interventions are still unknown. Therefore, the aim of the present study was to evaluate the effects of IFP with and without endurance-exercise training on body composition, food behavior, and lipid metabolism. Twenty-week-old Wistar rats were kept under an inverted circadian cycle of 12 h with water ad libitum and assigned to 4 different groups: control group (ad libitum feeding and sedentary), exercise group (ad libitum feeding and endurance training), intermittent fasting group (IF; intermittent fasting and sedentary), and intermittent fasting and exercise group (IFEX; intermittent fasting and endurance training). After 6 weeks, the body weight of IF and IFEX animals decreased without changes in food consumption. Yet, the body composition between the 2 groups was different, with the IFEX animals containing higher total protein and lower total fat content than the IF animals. The IFEX group also showed increases in total high-density lipoprotein cholesterol and increased intramuscular lipid content. The amount of brown adipose tissue was higher in IF and IFEX groups; however, the IFEX group showed higher expression levels of uncoupling protein 1 in this tissue, indicating a greater thermogenesis. The IFP combined with endurance training is an efficient method for decreasing body mass and altering fat metabolism, without inflicting losses in protein content.
间歇性禁食方案（IFP）已被提出作为改变身体代谢和改善健康的策略。IFP 的效果似乎与有氧运动相似，根据强度和频率具有适应的激效作用。然而，两者联合干预的效果仍不清楚。因此，本研究旨在评估 IFP 结合和不结合耐力运动训练对身体成分、食物行为和脂质代谢的影响。20 周龄的 Wistar 大鼠在 12 小时的昼夜颠倒周期中保持水自由摄取，并分为 4 个不同组：对照组（自由摄取和久坐）、运动组（自由摄取和耐力训练）、间歇性禁食组（IF；间歇性禁食和久坐）和间歇性禁食和运动组（IFEX；间歇性禁食和耐力训练）。6 周后，IF 和 IFEX 动物的体重下降，而食物消耗没有变化。然而，两组之间的身体成分不同，IFEX 动物的总蛋白质含量较高，总脂肪含量较低。IFEX 组的总高密度脂蛋白胆固醇也增加，肌肉内脂质含量增加。棕色脂肪组织的数量在 IF 和 IFEX 组中较高；然而，IFEX 组在该组织中表现出更高的解偶联蛋白 1 表达水平，表明产热增加。IFP 结合耐力训练是一种有效的降低体重和改变脂肪代谢的方法，而不会导致蛋白质含量损失。
