Ma Yan-Lei, Zhang Chao, Zhao Wan-Hui, Shi Shi, He Dan-Nv, Zhang Pan, Liu Xiao-Hong, Han Ting-Ting, Fu Yan-Hui, Liu Yan-Ping
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
Nat Prod Res. 2018 Sep;32(18):2159-2164. doi: 10.1080/14786419.2017.1367786. Epub 2017 Aug 22.
A new furanocoumarin, clauhainanin A (1), together with seven known furanocoumarins (2-8), were isolated from the stems and leaves of Clausena hainanensis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-8) were isolated from C. hainanensis for the first time. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-8 exhibited significant inhibitory effects with IC values ranging from 1.36 to 18.96 μM.
从海南黄皮的茎和叶中分离出一种新的呋喃香豆素——海南黄皮素A（1），以及七种已知的呋喃香豆素（2 - 8）。通过广泛的光谱方法阐明了1的结构，并通过与文献报道的数据进行比较鉴定了已知化合物。所有已知化合物（2 - 8）均首次从海南黄皮中分离得到。对所有分离得到的化合物进行了体外对五种人类癌细胞系HL - 60、SMMC - 7721、A - 549、MCF - 7和SW480的细胞毒性评估。化合物1 - 8表现出显著的抑制作用，IC值范围为1.36至18.96 μM。
