College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China; Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China.
College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China.
Chin J Nat Med. 2018 Jul;16(7):509-512. doi: 10.1016/S1875-5364(18)30087-6.
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
本研究对吴茱萸科吴茱萸属的枝叶甲醇提取物进行了植物化学研究，从中分离得到了 9 个咔唑生物碱（化合物 1-9），包括 2 个新的咔唑生物碱，克劳森斯 A 和 B（化合物 1 和 2）。新化合物的结构是基于广泛的光谱数据（MS、NMR、IR 和 UV）阐明的，而已知化合物则是通过将光谱数据与文献报道的数据进行比较来确定的。所有分离得到的化合物都进行了对 A549 和 Hela 癌细胞系的细胞毒性测试。结果表明，化合物 2-6 对癌细胞表现出不同程度的细胞毒性，IC 值范围为 8.67-98.89 μmol·L。
