Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University , Haikou , P. R. China.
Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University , Haikou , P. R. China.
Nat Prod Res. 2019 Dec;33(23):3337-3342. doi: 10.1080/14786419.2018.1475386. Epub 2018 May 17.
A phytochemical investigation on the stems and leaves of led to the isolation of a previously undescribed carbazole alkaloid, clausemargine A (), together with 11 known analogues (). The structure of was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (-) were isolated from for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 . Compounds - showed significant antiproliferative effects with IC values ranging from 0.28 to 15.18 μM.
对 茎和叶的植物化学研究导致了一种以前未被描述的咔唑生物碱克劳森马京 A（）的分离，以及 11 种已知类似物（）。通过广泛的光谱方法阐明了的结构，通过与文献中报道的数据进行比较鉴定了已知化合物。所有已知化合物（-）均首次从 中分离得到。所有分离得到的化合物均对五种人癌细胞系 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 的增殖活性进行了评估。化合物 - 表现出显著的增殖抑制活性，IC 值范围为 0.28 至 15.18 μM。
