Center for Advanced Translational Stroke Science, Departments of Neurology and Neuroscience, University of Kentucky, Lexington, KY 40536, United States.
Center for Advanced Translational Stroke Science, Departments of Neurology and Neuroscience, University of Kentucky, Lexington, KY 40536, United States.
Pharmacol Ther. 2018 Mar;183:50-57. doi: 10.1016/j.pharmthera.2017.08.008. Epub 2017 Aug 19.
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190kDa subunit couples with the 130kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
几种神经营养因子通过白血病抑制因子受体传递其信号。该 190kDa 亚基与 130kDa gp130 亚基偶联，在神经元和少突胶质细胞中转导细胞内信号，导致与神经存活相关基因的表达。此外，该受体的激活将免疫细胞的表型改变为抗炎表型。尽管已经在神经退行性疾病的背景下研究了激活白血病抑制因子受体的细胞因子，但与比较而言，对该特定受体亚基的治疗靶向研究较少。这篇综述检查了该受体在中枢神经系统和免疫系统中的作用及其在中风和其他脑部病变治疗中的应用。
