组胺H1受体拮抗剂替美斯汀对睡眠无影响。
No effects on sleep of a histamine H1-receptor antagonist: temelastine.
作者信息
Adam K, Oswald I
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):718-20. doi: 10.1111/j.1365-2125.1986.tb02963.x.
Abstract
Twelve volunteer poor sleepers of mean age 57 years took placebo on each of 3 consecutive nights, and temelastine 100 mg on 3 consecutive nights in a double-blind balanced order study. Sleep in the EEG laboratory was unaffected by the drug.
摘要
12名平均年龄57岁的睡眠不佳志愿者在一项双盲平衡试验研究中，连续3晚每晚服用安慰剂，然后连续3晚每晚服用100毫克替美斯汀。在脑电图实验室的睡眠未受该药物影响。
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本文引用的文献
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Daytime sleepiness and antihistamines.日间嗜睡与抗组胺药。
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Effects of two antihistamine drugs on actual driving performance.两种抗组胺药物对实际驾驶性能的影响。
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Br J Clin Pharmacol. 1986 Dec;22(6):715-7. doi: 10.1111/j.1365-2125.1986.tb02962.x.
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Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system.对SK&F 93944（替美斯汀）进行的药理学研究，SK&F 93944是一种新型组胺H1受体拮抗剂，穿透中枢神经系统的能力可忽略不计。
Br J Pharmacol. 1986 Mar;87(3):569-78. doi: 10.1111/j.1476-5381.1986.tb10199.x.
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A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour.五种抗组胺药对精神运动表现、中枢神经系统唤醒的客观评估以及睡眠和清晨行为主观评价的副作用的重复剂量比较。
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