Betts T, Markman D, Debenham S, Mortiboy D, McKevitt T
Br Med J (Clin Res Ed). 1984 Jan 28;288(6413):281-2. doi: 10.1136/bmj.288.6413.281.
A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures of mood and arousal, and despite an awareness that their driving was impaired while they were taking this agent subjects could not correct their performance. This study suggests that drivers who need antihistamine drugs should avoid those that act centrally.
进行了一项双盲安慰剂对照实验，以测量中枢性抗组胺药曲普利啶和外周性抗组胺药特非那定对一组经验丰富的女性驾驶员实际驾驶性能的影响。曲普利啶严重损害驾驶行为，而特非那定则没有。曲普利啶还损害了情绪和觉醒的主观及客观指标，尽管受试者意识到服用该药物时其驾驶能力受损，但他们无法纠正自己的驾驶表现。这项研究表明，需要服用抗组胺药的驾驶员应避免使用具有中枢作用的药物。
