Andronic Anca Andreea, Mihaila Sorina, Cinteza Mircea
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Department of Cardiology, Emergency University Hospital, Bucharest, Romania.
Maedica (Bucur). 2016 Dec;11(4):320-324.
Heart failure with midrange ejection fraction (HFmrEF) is a new category of heart failure (HF), inbetween HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Previous studies were mainly conducted in HFrEF patients having a left ventricle ejection fraction (LVEF) lower than 35-40%. Later on, HFpEF captured the spot-light of the research field, and studies focused on patients with HF symptoms, but with a LVEF exceeding 50%. Consequently, a gap of knowledge comprising the LVEF between 40 and 49% has arisen. Current studies focusing on patients with HFmrEF are arguing the same conclusions or even having contradictory findings. HFmrEF has a prevalence of 10-20% of HF patients. HFmrEF has distinct, but intermediate clinical, structural and functional characteristics, as well as intermediate outcomes in comparison with HFrEF and HFpEF. However, there is still a large gap in evidence regarding detailed hemodynamic characteristics, long-term follow-up and optimal therapeutic options for these patients. Extensive research was recommended in order to improve knowledge about this "gray area" of patients with HF. Therefore, we aimed to provide an over-view of the existing and lacking data regarding patients with HFmrEF.
射血分数介于中间范围的心力衰竭（HFmrEF）是心力衰竭（HF）的一种新类型，介于射血分数降低的心力衰竭（HFrEF）和射血分数保留的心力衰竭（HFpEF）之间。以往的研究主要在左心室射血分数（LVEF）低于35%-40%的HFrEF患者中进行。后来，HFpEF成为研究领域的焦点，研究集中在有HF症状但LVEF超过50%的患者身上。因此，出现了LVEF在40%至49%之间的知识空白。目前针对HFmrEF患者的研究得出的结论相同，甚至存在相互矛盾的结果。HFmrEF在HF患者中的患病率为10%-20%。与HFrEF和HFpEF相比，HFmrEF具有独特但处于中间状态的临床、结构和功能特征，以及中间的预后情况。然而，关于这些患者详细的血流动力学特征、长期随访和最佳治疗选择的证据仍然存在很大差距。建议进行广泛研究，以增进对这类HF患者“灰色地带”的了解。因此，我们旨在概述有关HFmrEF患者的现有数据和缺失数据。
