Horton Iain, Lin Yaxiong, Reed Gay, Wiepert Mathieu, Hart Steven
Mayo Clinic, Rochester, MN, 55905, USA.
J Pers Med. 2017 Aug 22;7(3):7. doi: 10.3390/jpm7030007.
Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient's genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse. The system is the foundation for Mayo Clinic to build a suite of tools and interfaces to support various clinical and research use cases. The genomic data warehouse is positioned to play a key role in enhancing the research capabilities and advancing individualized patient care at Mayo Clinic.
个性化医疗能够为患者做出更好的诊断和治疗决策,并推动对疾病分子基础的研究。将个体患者的基因组和分子信息与其临床表型联系起来对于这些努力至关重要。为满足这一需求,梅奥诊所个性化医疗中心已实施了一个基因组数据仓库和一个工作流管理系统,以将机构电子健康记录中的数据以及来自临床和研究生物信息学来源的基因组测序数据导入该仓库。该系统是梅奥诊所构建一套工具和接口以支持各种临床和研究用例的基础。基因组数据仓库在增强梅奥诊所的研究能力和推进个体化患者护理方面将发挥关键作用。