Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia.
Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia; Cognitive Neuropsychiatry Laboratory, Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia; Department of Psychiatry, St Vincent's Hospital, Melbourne, Australia.
J Affect Disord. 2018 Jan 1;225:147-152. doi: 10.1016/j.jad.2017.08.029. Epub 2017 Aug 15.
Although the study of cognition in first degree relatives (FDRs) is not new, findings in this group are still somewhat inconsistent and much of the research examining FDR populations include individuals under the age of 25, who are arguably still at significant risk to go on to develop BD. The present study aimed to establish the value of cognitive performance as a genuine endophenotypic marker of familial risk for bipolar disorder (BD), by examining cognition in FDRs aged 25 years or older.
The current study compared the cognitive performance of 27 unaffected FDRs to 47 healthy controls (HCs) and 28 BD patients using the MATRICS Consensus Cognitive Battery (MCCB).
Results indicated that FDRs had impaired verbal learning performance, as well as selective impairments on a measure of speed of processing; and a measure of spatial working memory compared to HC.
Limitations relate to the potential insensitivity of some of the tests in the MCCB for detecting cognitive deficits that have been previously noted in BD and FDR samples using other batteries.
Findings from this study implicate verbal learning, processing speed and working memory performance as promising candidate endophenotypes of familial risk for BD.
尽管对一级亲属（FDRs）的认知研究并非新鲜事物，但该群体的研究结果仍存在一定的不一致性，并且许多研究一级亲属群体的研究都包括年龄在 25 岁以下的个体，他们仍有很大的风险会发展为双相情感障碍（BD）。本研究旨在通过检查 25 岁及以上的 FDR 的认知表现，确定认知表现作为双相情感障碍（BD）家族风险的真正内表型标志物的价值。
本研究使用 MATRICS 共识认知电池（MCCB）比较了 27 名未受影响的 FDR 的认知表现与 47 名健康对照（HC）和 28 名 BD 患者。
结果表明，与 HC 相比，FDR 在言语学习表现以及在处理速度方面的选择性缺陷，以及空间工作记忆方面的表现受损。
本研究的局限性在于，MCCB 中的一些测试可能对之前使用其他电池在 BD 和 FDR 样本中检测到的认知缺陷不敏感。
本研究的结果表明，言语学习、处理速度和工作记忆表现是 BD 家族风险的有希望的候选内表型。
