Division of Infectious Diseases, University of Toronto, Canada.
Boston Children's Hospital.
J Infect Dis. 2016 Dec 1;214(suppl_4):S393-S398. doi: 10.1093/infdis/jiw343.
Our understanding of the global burden of antimicrobial resistance is limited. Complementary approaches to antimicrobial resistance surveillance are needed.
We developed a Web-based/mobile platform for aggregating, analyzing, and disseminating regional antimicrobial resistance information. Antimicrobial resistance indices from existing but disparate online sources were identified and abstracted. To validate antimicrobial resistance data, in the absence of regional comparators, US and Canadian indices were aggregated and compared to existing national and state estimates. Measures of variability of antimicrobial susceptibility were determined for the United States and Canada to evaluate magnitudes of differences within countries.
Over 850 resistance indices globally were identified and abstracted, totaling >5 million isolates, from 340 unique locations. Resistance index coverage spanned 41 countries, 6 continents, 43 of 50 US states, and 8 of 10 Canadian provinces. When compared to reported values, aggregated resistance values for the United States and Canada during 2013 and 2014 demonstrated agreements ranging from 94% to 97%. For the United States, state-specific resistance estimates demonstrated an agreement of 92%. Large differences in antimicrobial susceptibility were seen within countries.
Using existing nontraditional data sources, we have developed a Web-based platform for aggregating antimicrobial resistance indices to support monitoring of regional antimicrobial resistance patterns.
我们对抗菌药物耐药性的全球负担的了解有限。需要采用补充方法对抗菌药物耐药性进行监测。
我们开发了一个基于网络/移动的平台，用于汇总、分析和传播区域抗菌药物耐药性信息。从现有的但不同的在线来源中确定并提取了抗菌药物耐药性指数。为了验证抗菌药物耐药性数据，在没有区域对照的情况下，汇总了美国和加拿大的指数，并与现有的国家和州估计值进行了比较。为评估国家内部的差异程度，确定了美国和加拿大的抗菌药物敏感性变异性衡量标准。
全球范围内共确定和提取了超过 850 个耐药指数，总计来自 340 个不同地点的超过 500 万株分离株。耐药指数覆盖了 41 个国家、6 个大洲、美国的 43 个州和加拿大的 8 个省。与报告值相比，2013 年和 2014 年美国和加拿大汇总的耐药值的一致性从 94%到 97%不等。对于美国，各州的耐药估计值的一致性为 92%。在国家内部，抗菌药物敏感性存在较大差异。
我们使用现有的非传统数据来源，开发了一个基于网络的平台，用于汇总抗菌药物耐药性指数，以支持监测区域抗菌药物耐药模式。
