Canha Maria Inês, Oliveiros Bárbara, Franco Célia, Figueiredo Pedro
a Faculty of Medicine , University of Coimbra , Coimbra , Portugal.
b Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine , University of Coimbra (LBIM, FMUC) , Coimbra , Portugal.
Scand J Gastroenterol. 2017 Nov;52(11):1278-1285. doi: 10.1080/00365521.2017.1365167. Epub 2017 Aug 22.
To evaluate the association of lifestyle with the development of alcoholic liver disease (ALD) or alcoholic pancreatitis (AlcP).
A case-control study was conducted on 80 patients attending a tertiary university hospital, subdivided into three groups: ALD (n = 34), AlcP (n = 21) and a control (CT) group (n = 25) of alcohol abusers without clinical evidence of hepatic or pancreatic disease. Participants were interviewed regarding alcohol consumption, tobacco use and diet. A physical examination was concomitantly performed and we had access to their complementary investigation.
We included 10 females and 70 males (mean age 57 ± 10 years). The pure amount of alcohol consumed by the ALD group was significantly higher than the AlcP group, regarding both daily (grams/day) and lifetime (kilograms) consumptions (p = .018 and p = .009, respectively); no statistically significant differences were seen with the CT group. We found no differences regarding the beverage type or drinking outside meals. Smoking was very common in every study group, with higher consumptions and a significantly higher prevalence of ever smokers in the AlcP group, in comparison with ALD and CT patients (p = .033 and p = .036, respectively). There were significant differences in the patients' eating habits before the onset of disease between groups (p < .001), with ALD subjects reporting a less abundant diet and AlcP a more abundant diet in the past; most of the controls had unchanged habits.
We found differences in lifestyle between ALD and AlcP, not considered sufficient to explain the subjects' susceptibility to one disease or the other.
评估生活方式与酒精性肝病（ALD）或酒精性胰腺炎（AlcP）发生之间的关联。
对一家三级大学医院的80名患者进行了病例对照研究，将其分为三组：ALD组（n = 34）、AlcP组（n = 21）和对照组（CT组，n = 25），对照组为无肝脏或胰腺疾病临床证据的酗酒者。就饮酒、吸烟和饮食情况对参与者进行了访谈。同时进行了体格检查，并获取了他们的辅助检查结果。
我们纳入了10名女性和70名男性（平均年龄57±10岁）。就每日（克/天）和终生（千克）饮酒量而言，ALD组的纯酒精摄入量显著高于AlcP组（分别为p = 0.018和p = 0.009）；与CT组相比，未发现统计学上的显著差异。在饮料类型或餐外饮酒方面，我们未发现差异。吸烟在每个研究组中都很常见，与ALD组和CT组患者相比，AlcP组的吸烟量更高，既往吸烟者的患病率显著更高（分别为p = 0.033和p = 0.036）。各组患者在疾病发作前的饮食习惯存在显著差异（p < 0.001），ALD组患者报告过去饮食不太丰富，而AlcP组过去饮食更丰富；大多数对照组患者的饮食习惯没有变化。
我们发现ALD和AlcP患者在生活方式上存在差异，但这些差异不足以解释受试者对这两种疾病的易感性。
